{"id":"W2112068705","doi":"10.3109/10428194.2015.1068306","title":"Silibinin suppresses NPM-ALK, potently induces apoptosis and enhances chemosensitivity in ALK-positive anaplastic large cell lymphoma","year":2015,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Silymarin and Mushroom Poisoning","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Silibinin; Anaplastic lymphoma kinase; Cancer research; Anaplastic large-cell lymphoma; Survivin; Protein kinase B; Chemistry; Cell growth; Apoptosis; Biology; Lymphoma; Medicine; Immunology; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008706506,0.001147137,0.001677896,0.0006537958,0.0004059269,0.0002818593,0.0003427842,0.0008561484,0.0000304042],"category_scores_gemma":[0.0005494475,0.001088197,0.000243267,0.0009870252,0.0005932279,0.0008144205,0.000573029,0.0002685672,0.00006544629],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004501184,"about_ca_system_score_gemma":0.003603574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003709597,"about_ca_topic_score_gemma":0.0004271348,"domain_scores_codex":[0.9941677,0.0003342825,0.001082432,0.001748415,0.0009734181,0.001693705],"domain_scores_gemma":[0.9963833,0.0008134457,0.0004309398,0.000786706,0.0003087995,0.001276811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01369578,0.005799425,0.09698815,0.002630708,0.001287655,0.005330016,0.03243082,0.000105321,0.3117102,0.00154905,0.01199881,0.516474],"study_design_scores_gemma":[0.07773247,0.001553753,0.3022779,0.00152174,0.0007239656,0.00252673,0.01002728,0.006280955,0.5880429,0.0004044979,0.006539701,0.002368144],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788705,0.003651241,0.00006773664,0.0002697025,0.0006250304,0.0008176165,0.00008793236,0.0002916393,0.01531867],"genre_scores_gemma":[0.9948614,0.0009621947,0.0006648026,0.001465043,0.0004440775,0.000106924,0.0001843156,0.0001601288,0.001151175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5141059,"threshold_uncertainty_score":0.9993204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267269262193477,"score_gpt":0.2413551820654554,"score_spread":0.2286824894435207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}