{"id":"W2112084205","doi":"10.1002/gene.20019","title":"Transition nuclear proteins are required for normal chromatin condensation and functional sperm development","year":2004,"lang":"en","type":"article","venue":"genesis","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute","keywords":"Protamine; Chromatin; Biology; Histone; Sperm; Cell biology; Prophase; Intracytoplasmic sperm injection; Sterility; Chromatin remodeling; Andrology; Genetics; Embryo; DNA; Gene; Biochemistry; Meiosis; In vitro fertilisation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008110201,0.00008320966,0.0001082806,0.00005560823,0.0001369626,0.0000126671,0.00001023549,0.00006412357,0.0001066539],"category_scores_gemma":[0.00003586332,0.00007798927,0.00003632245,0.00006183219,0.00002328911,0.00007204032,0.000004643932,0.00002787098,0.00002846154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009579738,"about_ca_system_score_gemma":0.00007688964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001591899,"about_ca_topic_score_gemma":0.00001084473,"domain_scores_codex":[0.9994377,0.000006804245,0.0001400155,0.000162457,0.0001428556,0.000110132],"domain_scores_gemma":[0.9997307,0.00000970862,0.00004479158,0.00006927815,0.00008546159,0.00006005692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001324828,0.0004622006,0.004161367,0.0007503919,0.0002257051,0.00003312218,0.00349311,0.0004654673,0.9627995,0.001384152,0.0004741499,0.02442604],"study_design_scores_gemma":[0.005768409,0.0004416442,0.8983983,0.0001826422,0.0001928875,0.0002478227,0.0006436454,0.0006398566,0.09022731,0.0003127962,0.002703189,0.000241542],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778395,0.00007818881,0.02037949,0.0008812075,0.00009793857,0.0005627375,0.000005437051,0.00006992583,0.0000855789],"genre_scores_gemma":[0.9846563,0.000005242304,0.01453244,0.0003332806,0.0001943948,0.00007093527,0.0001054469,0.00001711277,0.00008486254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8942369,"threshold_uncertainty_score":0.318031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02515463739779812,"score_gpt":0.2237974886672078,"score_spread":0.1986428512694097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}