{"id":"W2112127173","doi":"10.1084/jem.191.6.977","title":"Blockade of the Bcr-Abl Kinase Activity Induces Apoptosis of Chronic Myelogenous Leukemia Cells by Suppressing Signal Transducer and Activator of Transcription 5–Dependent Expression of Bcl-XL","year":2000,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":364,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; University of Minnesota","keywords":"Chronic myelogenous leukemia; STAT protein; STAT5; breakpoint cluster region; Cancer research; ABL; K562 cells; Signal transduction; Apoptosis; Biology; Kinase; Leukemia; STAT3; Cell biology; Tyrosine kinase; Immunology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001253197,0.0002304579,0.0001500122,0.0001312525,0.0001163102,0.0001924017,0.0001008655,0.0001249527,0.001041368],"category_scores_gemma":[0.00006357025,0.00007444774,0.0001172601,0.000128541,0.0001697937,0.0001185392,0.0001253594,0.0005074539,0.0001899181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835814,"about_ca_system_score_gemma":0.0001926716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002122271,"about_ca_topic_score_gemma":0.0004479504,"domain_scores_codex":[0.9999067,0.00001358536,0.000008825586,0.00001139943,0.00002689257,0.00003256261],"domain_scores_gemma":[0.9999598,0.00000948861,0.00001125888,0.000005984802,0.00000347452,0.00001002287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001393026,0.00007220187,0.0001483754,0.00002835991,0.00000392051,0.00002574611,0.000009635559,0.00005480893,0.9970466,0.0001951687,0.00004185735,0.002233973],"study_design_scores_gemma":[0.0001182807,0.0008888957,0.00402565,0.000007570757,0.00001612724,0.0002621009,0.00001815978,0.001018017,0.9897025,0.0001048017,0.003835235,0.000002571039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959682,0.001598003,0.001086145,0.0001024591,0.00001908382,0.00002067812,0.0001283428,0.00002825318,0.001048812],"genre_scores_gemma":[0.9971968,0.000972023,0.0007100446,0.00002989682,0.00001062887,0.00002093713,0.0002294991,0.000003684021,0.0008265525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001041368,"threshold_uncertainty_score":0.003483772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0144349625745394,"score_gpt":0.2611755670376567,"score_spread":0.2467406044631173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}