{"id":"W2112128648","doi":"10.1161/01.res.0000029232.42227.16","title":"Inducible Expression of BNIP3 Provokes Mitochondrial Defects and Hypoxia-Mediated Cell Death of Ventricular Myocytes","year":2002,"lang":"en","type":"article","venue":"Circulation Research","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":316,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Myocyte; Programmed cell death; Mitochondrial permeability transition pore; Cell biology; Mitochondrion; Apoptosis; Biology; Hypoxia (environmental); Cytosol; Molecular biology; Internal medicine; Chemistry; Biochemistry; Medicine; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002483655,0.00008530959,0.0002230229,0.0003023811,0.00007134388,0.00001040243,0.00006954625,0.0001214901,0.0002858684],"category_scores_gemma":[0.0003196037,0.00007214485,0.00006390309,0.0003815389,0.0001124258,0.00008463213,0.00003720072,0.0001772694,0.00001745596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003034492,"about_ca_system_score_gemma":0.00006399802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002744905,"about_ca_topic_score_gemma":3.146034e-7,"domain_scores_codex":[0.998526,0.0001500089,0.0002481235,0.0002253355,0.0006387989,0.0002117],"domain_scores_gemma":[0.9989461,0.0002330607,0.00008898528,0.0002814746,0.0003136916,0.0001367125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001482513,0.0004570969,0.09097107,0.0003163267,0.00002369876,0.00002803654,0.0004030071,0.0000503822,0.9065403,0.0000911399,0.0004112965,0.0005593755],"study_design_scores_gemma":[0.002660107,0.0002856049,0.2185201,0.0001961411,0.00003263855,0.000007275787,0.0001039797,0.002283459,0.7751852,0.000445547,0.0001975929,0.00008231797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937759,0.003714497,0.00005052014,0.00004327051,0.00004159436,0.0006203221,0.000006795679,0.00001853617,0.001728546],"genre_scores_gemma":[0.9993118,0.0001884009,0.0001670197,0.00001284509,0.00009275555,0.00002772967,0.00002639562,0.00001502076,0.0001580254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1313551,"threshold_uncertainty_score":0.3130059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0775854348320213,"score_gpt":0.3335070785389533,"score_spread":0.255921643706932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}