{"id":"W2112142146","doi":"10.1139/v09-083","title":"Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol–adenosine hybrids as inhibitors of 17β-hydroxysteroid dehydrogenase type 1","year":2009,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Moiety; Sonogashira coupling; Stereochemistry; Steroid; Hydroxysteroid dehydrogenase; Adenosine; Dehydrogenase; In vitro; Estrone; Cofactor; Alkene; Biological activity; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635088,0.0003501958,0.000401754,0.0001559577,0.0001069928,0.0002973959,0.0002749004,0.0002467181,0.0008966646],"category_scores_gemma":[0.0001815991,0.0002186136,0.0002106947,0.0001687409,0.0001345304,0.0001625827,0.000157566,0.0003204446,0.0003105821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479943,"about_ca_system_score_gemma":0.0001800632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005222962,"about_ca_topic_score_gemma":0.001328264,"domain_scores_codex":[0.999878,0.00003095617,0.00001214824,0.00002132286,0.00003207588,0.0000253788],"domain_scores_gemma":[0.9999202,0.00001496671,0.00002435896,0.000008738488,0.00001391437,0.00001780364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001893263,0.0000560351,0.0001078096,0.00006386977,0.00002073435,0.00008749415,0.00002532586,0.001009688,0.9944891,0.0001518918,0.00003479165,0.003763996],"study_design_scores_gemma":[0.00008073833,0.001757681,0.0009934941,0.000005788884,0.00006381807,0.0001801457,0.00001971595,0.0008440939,0.9903115,0.00002834271,0.005699465,0.00001513085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987062,0.004121406,0.005795934,0.00005351751,0.00003682138,0.000189708,0.0003306156,0.00006583118,0.00234405],"genre_scores_gemma":[0.9842369,0.00263332,0.009865612,0.00005076844,0.00002078155,0.0001155098,0.0005775712,0.00001608249,0.002483433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008966646,"threshold_uncertainty_score":0.002999663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03151506021449926,"score_gpt":0.2855853810112032,"score_spread":0.254070320796704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}