{"id":"W2112162466","doi":"10.1158/1078-0432.ccr-04-2047","title":"Antisense Inhibition of Methylenetetrahydrofolate Reductase Reduces Cancer Cell Survival <i>In vitro</i> and Tumor Growth <i>In vivo</i>","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"","keywords":"In vivo; Cisplatin; Methylenetetrahydrofolate reductase; Cytotoxic T cell; Growth inhibition; Cancer research; Cell growth; Biology; Pharmacology; Colorectal cancer; Cancer; Medicine; In vitro; Internal medicine; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126517,0.0004188498,0.0002569535,0.0001514844,0.0001075353,0.0001748989,0.0001418853,0.0002067595,0.0009719214],"category_scores_gemma":[0.0001118589,0.00009912466,0.0002220991,0.00009712263,0.000144962,0.0001239966,0.00006433322,0.0004326463,0.0001746664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003381609,"about_ca_system_score_gemma":0.000220065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001504423,"about_ca_topic_score_gemma":0.002104043,"domain_scores_codex":[0.9998999,0.00001279928,0.00001193297,0.00002619265,0.00002732698,0.00002187879],"domain_scores_gemma":[0.999907,0.00002596995,0.0000270874,0.000006685823,0.00001458236,0.00001867301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001526974,0.00005359348,0.0001979808,0.00004549721,0.000006728321,0.000009537389,0.000005815607,0.00006530376,0.9982721,0.00002667602,0.00005208214,0.001111974],"study_design_scores_gemma":[0.00002626499,0.001455321,0.002362809,0.000004678203,0.00002829744,0.00009155944,0.000008919728,0.0005355986,0.9943663,0.000009103508,0.001108681,0.00000238798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925019,0.004228671,0.001499536,0.0001121762,0.00005902458,0.00002939705,0.0003229618,0.00007566095,0.001170576],"genre_scores_gemma":[0.9919471,0.003085103,0.002276533,0.00008321021,0.00002783554,0.00004855085,0.0008224745,0.00001521084,0.001694091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504423,"threshold_uncertainty_score":0.003251374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1107980950473606,"score_gpt":0.4649986918685726,"score_spread":0.354200596821212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}