{"id":"W2112267696","doi":"10.3389/fimmu.2013.00172","title":"Re-Directing CD4+ T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough","year":2013,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"MHC class I; MHC class II; Core (optical fiber); Class (philosophy); Computational biology; Major histocompatibility complex; Chemistry; Biology; Genetics; Immune system; Computer science; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.000806424,0.0004754299,0.000832271,0.0003389779,0.001034356,0.00003989973,0.001365829,0.0007090935,0.0005347665],"category_scores_gemma":[0.0002007282,0.0002811851,0.0001763692,0.00050868,0.002846438,0.0001853931,0.0005064094,0.001472016,0.0002053473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001171741,"about_ca_system_score_gemma":0.000199299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002006471,"about_ca_topic_score_gemma":0.0004833338,"domain_scores_codex":[0.9963826,0.001070645,0.0007678998,0.0006428029,0.00009488824,0.001041191],"domain_scores_gemma":[0.9968101,0.0011508,0.0006066252,0.001213513,0.000201344,0.00001757268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001603318,0.0001885522,0.01033427,0.00002699196,0.0006126948,0.00001273809,0.0109586,0.0000104275,0.911869,0.0002966046,0.06060841,0.003478413],"study_design_scores_gemma":[0.00342304,0.001488473,0.01092401,0.0001391905,0.0001620041,0.0001675897,0.03925007,0.00001700933,0.7594733,0.001030381,0.1833037,0.0006211747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654701,0.02149218,0.00009489875,0.006123272,0.00216049,0.0007620756,0.00002172028,0.0001037647,0.00377149],"genre_scores_gemma":[0.9762742,0.0008215597,0.0005436189,0.0009858198,0.00005140179,0.0001558727,0.00003194709,0.00005618659,0.02107941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1523957,"threshold_uncertainty_score":0.9999641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01402613611158963,"score_gpt":0.2192862965547612,"score_spread":0.2052601604431716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}