{"id":"W2112288351","doi":"10.1158/0008-5472.can-10-3172","title":"Disruption of a <i>Sirt1</i>-Dependent Autophagy Checkpoint in the Prostate Results in Prostatic Intraepithelial Neoplasia Lesion Formation","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute","keywords":"Autophagy; Prostate cancer; Cancer research; Prostate; Biology; Androgen receptor; Histone; Sirtuin 1; Sirtuin; BAG3; Intraepithelial neoplasia; Cancer; Cell biology; Gene; Genetics; Apoptosis; Downregulation and upregulation; Acetylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001198115,0.0003235068,0.0002563667,0.0003647138,0.0002029281,0.0003477751,0.0002133539,0.0002582565,0.001973265],"category_scores_gemma":[0.00008519225,0.0002357051,0.0004101025,0.0002254956,0.0003397739,0.0001853763,0.0002512723,0.0006511621,0.0005385962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003125669,"about_ca_system_score_gemma":0.0003309298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000942045,"about_ca_topic_score_gemma":0.001512624,"domain_scores_codex":[0.9998389,0.00002708238,0.00001718177,0.00003422398,0.00004766851,0.00003485059],"domain_scores_gemma":[0.9998696,0.00001563331,0.00003870577,0.00002035139,0.0000066752,0.00004904603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001046045,0.00003335169,0.0001641543,0.00002142525,0.000008046277,0.00007417496,0.000009199527,0.00006261282,0.9984552,0.0001990712,0.00005082335,0.0008173248],"study_design_scores_gemma":[0.00001419321,0.0002248375,0.004777246,0.00000380885,0.00001652434,0.0004473933,0.00002716273,0.0007051866,0.991911,0.00007862098,0.001788712,0.00000529567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992376,0.001170456,0.003237901,0.0001644646,0.0000588499,0.00002605138,0.0005651821,0.0003367563,0.002064382],"genre_scores_gemma":[0.9944835,0.0005054566,0.00137456,0.00006034447,0.000006414859,0.00001572814,0.0005424889,0.00005011729,0.002961314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001973265,"threshold_uncertainty_score":0.006601274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05673000660606387,"score_gpt":0.4115998480632752,"score_spread":0.3548698414572113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}