{"id":"W2112314514","doi":"10.1128/jvi.77.18.9817-9822.2003","title":"Specific Inhibition of the Synthesis of Human Lysyl-tRNA Synthetase Results in Decreases in tRNA Lys Incorporation, tRNA 3 Lys Annealing to Viral RNA, and Viral Infectivity in Human Immunodeficiency Virus Type 1","year":2003,"lang":"en","type":"article","venue":"Journal of Virology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Foundation for AIDS Research","keywords":"Transfer RNA; Primer binding site; RNA; Transfection; Molecular biology; Biology; Physics; Cell culture; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001789445,0.0004870047,0.000310657,0.0001750477,0.000172769,0.0005138117,0.0004397729,0.0003275587,0.008210373],"category_scores_gemma":[0.0002613149,0.0002890476,0.0003544576,0.0002292067,0.0002399741,0.0001960192,0.0001741802,0.001018015,0.002740817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005855425,"about_ca_system_score_gemma":0.0005232074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001435061,"about_ca_topic_score_gemma":0.002550422,"domain_scores_codex":[0.9997202,0.00004867434,0.00003471662,0.00005403504,0.00007456046,0.00006785674],"domain_scores_gemma":[0.9997731,0.00008988714,0.00003347207,0.00003598822,0.00001723193,0.00005028224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004061828,0.0001468041,0.0001092848,0.00005749783,0.00001070274,0.00003978396,0.00001607378,0.0001681616,0.996492,0.0002511418,0.0005306281,0.001771826],"study_design_scores_gemma":[0.00001763056,0.0001873568,0.001006538,0.000004589177,0.000007138997,0.00003575771,0.000008206629,0.0006903746,0.9951568,0.00003715172,0.002844586,0.000003813814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754364,0.002077945,0.005022644,0.0003776232,0.0002847495,0.00009138469,0.003445472,0.0007889521,0.01247473],"genre_scores_gemma":[0.9397765,0.001458215,0.007353808,0.000281105,0.00004172154,0.0001392462,0.01099273,0.0004549157,0.03950182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008210373,"threshold_uncertainty_score":0.02746642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01199166219082875,"score_gpt":0.2404326124427016,"score_spread":0.2284409502518728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}