{"id":"W2112321133","doi":"10.1371/journal.pgen.1003270","title":"ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":246,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sleep & Circadian Network; Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"UCB Pharma; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Wellcome Trust; Agence Nationale de la Recherche; National Human Genome Research Institute; Münchner Zentrum für Gesundheitswissenschaften; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; National Institutes of Health; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Cincinnati Children's Hospital Medical Center; Juvenile Diabetes Research Foundation International","keywords":"Narcolepsy; Biology; Immunology; Human leukocyte antigen; Major histocompatibility complex; Genetics; T-cell receptor; Antigen; T cell; Immune system; Neuroscience; Neurology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009055179,0.0001121014,0.0001225346,0.0001721664,0.00008329534,0.0001293526,0.000445848,0.0000374316,0.0001690054],"category_scores_gemma":[0.00013515,0.0001043984,0.00002211396,0.0005141179,0.00003744741,0.00008338552,0.0002030579,0.0001285142,0.00118683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002659091,"about_ca_system_score_gemma":0.00002463034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009950977,"about_ca_topic_score_gemma":0.00002761888,"domain_scores_codex":[0.9984496,0.0001700479,0.0002170332,0.0003757282,0.0004121235,0.0003754387],"domain_scores_gemma":[0.9992473,0.0001584818,0.00002978575,0.000389965,0.00005977902,0.0001147468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001062611,0.000551485,0.05890128,0.000006447834,0.000003980975,0.000006068333,0.001211131,0.0001862357,0.9357351,0.00001056645,0.0001948931,0.003182202],"study_design_scores_gemma":[0.0003107654,0.000219808,0.07878152,0.000005408169,0.000002834709,7.69828e-7,0.0004332947,0.002214909,0.9174897,0.0003339515,0.00008692074,0.0001201272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969965,0.00003384426,0.00002718627,0.0002717081,0.00007921668,0.001804647,0.000005125457,0.00003355051,0.0007481849],"genre_scores_gemma":[0.9990252,0.00002792943,0.0001182024,0.0001805579,0.00004352091,0.000389491,9.623514e-7,0.00002214585,0.0001919459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01988025,"threshold_uncertainty_score":0.9995909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06589659342841599,"score_gpt":0.3256505584451436,"score_spread":0.2597539650167277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}