{"id":"W2112321133","doi":"10.1371/journal.pgen.1003270","title":"ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":246,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sleep & Circadian Network; Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"UCB Pharma; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Wellcome Trust; Agence Nationale de la Recherche; National Human Genome Research Institute; Münchner Zentrum für Gesundheitswissenschaften; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; National Institutes of Health; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Cincinnati Children's Hospital Medical Center; Juvenile Diabetes Research Foundation International","keywords":"Narcolepsy; Biology; Immunology; Human leukocyte antigen; Major histocompatibility complex; Genetics; T-cell receptor; Antigen; T cell; Immune system; Neuroscience; Neurology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002199527,0.0001401389,0.0001606705,0.0005141501,0.0001689934,0.0002589723,0.0001386102,0.0002388462,0.001696207],"category_scores_gemma":[0.0004785013,0.0001040636,0.0001913229,0.0003987858,0.0001542276,0.00005283657,0.0001771502,0.0001684755,0.0002542841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344294,"about_ca_system_score_gemma":0.0001050149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001322447,"about_ca_topic_score_gemma":0.001847999,"domain_scores_codex":[0.9997661,0.00004834399,0.00001261033,0.00009145278,0.00004099081,0.00004051696],"domain_scores_gemma":[0.9996883,0.000103766,0.00009361397,0.00003408655,0.00002756738,0.00005267212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009607133,0.00008483154,0.3155887,0.00005485368,0.0002462807,0.0005509328,0.0002666283,0.0004272934,0.6680347,0.0001922115,0.0005350694,0.01305781],"study_design_scores_gemma":[0.00001222893,0.0001361157,0.9856075,0.000003469086,0.00007287539,0.0007643013,0.00006389331,0.0004162822,0.01215929,0.0001181439,0.000640453,0.000005398249],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998161,0.0001189533,0.0008026932,0.00003530742,0.000006255037,0.000003540083,0.0003799272,0.00002041143,0.0004718124],"genre_scores_gemma":[0.9982388,0.00007786035,0.000585914,0.00004904782,0.000008421413,0.000008067759,0.0004666877,0.000007791833,0.0005573521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696207,"threshold_uncertainty_score":0.005674362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06589659342841599,"score_gpt":0.3256505584451436,"score_spread":0.2597539650167277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}