{"id":"W2112329697","doi":"10.1016/j.cell.2010.05.008","title":"Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations","year":2010,"lang":"en","type":"article","venue":"Cell","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":1204,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute on Aging; National Institutes of Health; NYU Langone Medical Center","keywords":"Autophagy; Biology; Lysosome; Presenilin; Proteolysis; Cell biology; TFEB; Protein subunit; Sequestosome 1; ATG16L1; Batten disease; Alzheimer's disease; Biochemistry; Enzyme; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008619855655993564,"score_gpt":0.2613236964601961,"score_spread":0.2527038408042026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}