{"id":"W2112345742","doi":"10.1161/atvbaha.112.250043","title":"Proprotein Convertase Subtilisin/Kexin Type 9 Interacts With Apolipoprotein B and Prevents Its Intracellular Degradation, Irrespective of the Low-Density Lipoprotein Receptor","year":2012,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute","keywords":"PCSK9; Kexin; Apolipoprotein B; LDL receptor; Proprotein convertase; Endocrinology; Internal medicine; Lipoprotein; Chemistry; Cholesterol; Low-density lipoprotein; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001994161,0.0004873763,0.0003350475,0.0002144182,0.0001646147,0.0004076227,0.0002668849,0.0003719047,0.00151064],"category_scores_gemma":[0.0001803663,0.0001650843,0.0003076768,0.000135957,0.0003682493,0.0002124473,0.0002703595,0.0005283643,0.0005684922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000351538,"about_ca_system_score_gemma":0.0002162371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003937189,"about_ca_topic_score_gemma":0.0004974002,"domain_scores_codex":[0.9996594,0.00004379892,0.00003687117,0.00008581655,0.0001091353,0.00006502574],"domain_scores_gemma":[0.9997632,0.00002448357,0.0001048197,0.0000289011,0.00002288422,0.00005576163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000186846,0.00002412785,0.0002879367,0.00003526026,0.000008609937,0.0000532411,0.000004017226,0.00002207832,0.9984509,0.00004120448,0.00002181664,0.0008640236],"study_design_scores_gemma":[0.00003081386,0.0002923437,0.005197668,0.000007858886,0.00001594926,0.0004012361,0.00001374924,0.0004170123,0.9922743,0.00002961594,0.001315653,0.000003778161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929662,0.001885902,0.003369457,0.0001232592,0.00004744977,0.00003167427,0.0002380053,0.0001036237,0.001234466],"genre_scores_gemma":[0.9922526,0.000813415,0.003549796,0.00006213954,0.00001611964,0.00003929773,0.0003863072,0.00002350844,0.00285688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00151064,"threshold_uncertainty_score":0.005053639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471697998025913,"score_gpt":0.2643236015072898,"score_spread":0.2396066215270307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}