{"id":"W2112345742","doi":"10.1161/atvbaha.112.250043","title":"Proprotein Convertase Subtilisin/Kexin Type 9 Interacts With Apolipoprotein B and Prevents Its Intracellular Degradation, Irrespective of the Low-Density Lipoprotein Receptor","year":2012,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute","keywords":"PCSK9; Kexin; Apolipoprotein B; LDL receptor; Proprotein convertase; Endocrinology; Internal medicine; Lipoprotein; Chemistry; Cholesterol; Low-density lipoprotein; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009125215,0.0003589763,0.0008106797,0.0000981923,0.000235381,0.00002912484,0.0001407234,0.0002545723,0.00007929796],"category_scores_gemma":[0.0001680946,0.0002251892,0.0002100058,0.000288769,0.0003807299,0.0002187135,0.0001879876,0.0003270385,0.00001221422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007492291,"about_ca_system_score_gemma":0.0001130046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055168,"about_ca_topic_score_gemma":0.0001482332,"domain_scores_codex":[0.9976647,0.000470072,0.0004662324,0.0005314657,0.00034421,0.000523325],"domain_scores_gemma":[0.9983475,0.00003642114,0.000272308,0.0007736999,0.0002723642,0.0002976688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002147591,0.0007985126,0.1926812,0.0007716939,0.001425936,2.67038e-7,0.001933603,3.226193e-7,0.7932643,0.0007475602,0.00006852571,0.008093272],"study_design_scores_gemma":[0.001764552,0.0009265288,0.8088011,0.0005358479,0.0003078043,0.000009825622,0.0002513482,0.00001953253,0.1864086,0.00002834906,0.0006876145,0.0002589125],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954235,0.001119575,0.0002130667,0.0005346047,0.0002043467,0.002419685,0.00002207193,0.0000353455,0.00002778463],"genre_scores_gemma":[0.9972957,0.001204174,0.0008114965,0.0002608907,0.0001940701,0.0001320678,0.00003613746,0.00004450342,0.00002097761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6161199,"threshold_uncertainty_score":0.918295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471697998025913,"score_gpt":0.2643236015072898,"score_spread":0.2396066215270307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}