{"id":"W2112404965","doi":"10.1186/alzrt266","title":"Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment","year":2014,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Medical Center, University of Rochester; National Institute on Aging; University of California, San Francisco; Canadian Institutes of Health Research; Pfizer; University of California, Los Angeles; National Institutes of Health; Jewish General Hospital; University of California, Davis; Foundation for the National Institutes of Health; University of Southern California; Eisai; Northern California Institute for Research and Education; Genentech; University of South Florida; USF Health Byrd Alzheimer's Institute; McGill University; Dartmouth College; Novartis Pharmaceuticals Corporation; Case Western Reserve University; IXICO; University of Pittsburgh; University of California, San Diego; Johns Hopkins University; Cleveland Clinic; York University; University of Rochester; Northwestern University; Biogen; BioClinica; Meso Scale Diagnostics; Rush University; F. Hoffmann-La Roche; University of Pennsylvania; Wake Forest University; Ohio State University; Synarc; Yale University; Bristol-Myers Squibb; Medpace; Emory University; Alzheimer's Association; Brigham and Women's Hospital; Eli Lilly and Company; University of California, Irvine; Georgetown University; Servier","keywords":"Neurology; Geriatric psychiatry; Cerebrospinal fluid; Cognitive impairment; Cognition; Medicine; Complement (music); Cognitive decline; Factor H; Internal medicine; Clinical psychology; Psychology; Dementia; Psychiatry; Complement system; Immunology; Disease; Chemistry; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004832094,0.0005436916,0.000315476,0.0007892411,0.0003403865,0.0004946183,0.0003360214,0.0004603083,0.002306298],"category_scores_gemma":[0.001741083,0.0001553225,0.000289079,0.000445033,0.0003164716,0.0002400175,0.0003068644,0.000409273,0.0003026255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003007195,"about_ca_system_score_gemma":0.0003363171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008143232,"about_ca_topic_score_gemma":0.004501526,"domain_scores_codex":[0.9998709,0.00002314274,0.00001499461,0.00003495206,0.00003400507,0.00002204764],"domain_scores_gemma":[0.9992628,0.0001206219,0.0003402361,0.00003293122,0.0001158018,0.0001276575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006605317,0.00006136276,0.995544,0.00002309319,0.0000592889,0.0000850083,0.00006744195,0.00006157989,0.0008694635,0.00001573131,0.0001323445,0.002420143],"study_design_scores_gemma":[0.0000108077,0.0001330683,0.998989,0.000007900636,0.00003008234,0.0002590562,0.00005039247,0.000176321,0.0001965405,0.00005400686,0.00009029701,0.000002466645],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991596,0.0002795816,0.00008935223,0.00002599916,0.000005485475,0.000007413168,0.0001429552,0.000007428638,0.00028228],"genre_scores_gemma":[0.9994956,0.00005109462,0.00009791002,0.00001298356,0.000006342812,0.000003440138,0.0001294757,7.966567e-7,0.0002024112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008143232,"threshold_uncertainty_score":0.01619172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2008054792411067,"score_gpt":0.3985728069917373,"score_spread":0.1977673277506306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}