{"id":"W2112404965","doi":"10.1186/alzrt266","title":"Low levels of cerebrospinal fluid complement 3 and factor H predict faster cognitive decline in mild cognitive impairment","year":2014,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Medical Center, University of Rochester; National Institute on Aging; University of California, San Francisco; Canadian Institutes of Health Research; Pfizer; University of California, Los Angeles; National Institutes of Health; Jewish General Hospital; University of California, Davis; Foundation for the National Institutes of Health; University of Southern California; Eisai; Northern California Institute for Research and Education; Genentech; University of South Florida; USF Health Byrd Alzheimer's Institute; McGill University; Dartmouth College; Novartis Pharmaceuticals Corporation; Case Western Reserve University; IXICO; University of Pittsburgh; University of California, San Diego; Johns Hopkins University; Cleveland Clinic; York University; University of Rochester; Northwestern University; Biogen; BioClinica; Meso Scale Diagnostics; Rush University; F. Hoffmann-La Roche; University of Pennsylvania; Wake Forest University; Ohio State University; Synarc; Yale University; Bristol-Myers Squibb; Medpace; Emory University; Alzheimer's Association; Brigham and Women's Hospital; Eli Lilly and Company; University of California, Irvine; Georgetown University; Servier","keywords":"Neurology; Geriatric psychiatry; Cerebrospinal fluid; Cognitive impairment; Cognition; Medicine; Complement (music); Cognitive decline; Factor H; Internal medicine; Clinical psychology; Psychology; Dementia; Psychiatry; Complement system; Immunology; Disease; Chemistry; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008783865,0.000216676,0.0002741319,0.0003498413,0.0001964746,0.000089572,0.0002466376,0.00005899365,0.0006696312],"category_scores_gemma":[0.0002894592,0.0001880151,0.00005703379,0.0004028135,0.0003154401,0.0002233183,0.0001835154,0.0003337783,0.00005490982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000157093,"about_ca_system_score_gemma":0.00008095543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002183282,"about_ca_topic_score_gemma":0.00003221233,"domain_scores_codex":[0.9960597,0.001312291,0.0004785771,0.0006121429,0.001028304,0.0005089873],"domain_scores_gemma":[0.998108,0.001092146,0.0001127185,0.0002178995,0.0002813514,0.000187937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001023402,0.0004407856,0.001583394,0.00001693546,0.00003986602,0.00001040491,0.001120618,0.000005556667,0.9661904,0.0009213519,0.00008192084,0.02856539],"study_design_scores_gemma":[0.003913993,0.00191266,0.0452552,0.00007707882,0.000007466228,0.000006028395,0.0001214476,0.001860278,0.9459411,0.0003522577,0.0003889267,0.0001635686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958864,0.0001503238,0.001075592,0.0008058405,0.00009954823,0.001524843,0.0002006326,0.00003406013,0.0002227359],"genre_scores_gemma":[0.9977365,0.0003852194,0.00007503195,0.00150106,0.00007814752,0.0001119257,0.000009768882,0.00003198717,0.00007041118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0436718,"threshold_uncertainty_score":0.7667035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2008054792411067,"score_gpt":0.3985728069917373,"score_spread":0.1977673277506306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}