{"id":"W2112414994","doi":"10.1128/aac.46.12.4029-4034.2002","title":"Pharmacodynamic Modeling of Clarithromycin against Macrolide-Resistant [PCR-Positive <i>mef</i> (A) or <i>erm</i> (B)] <i>Streptococcus pneumoniae</i> Simulating Clinically Achievable Serum and Epithelial Lining Fluid Free-Drug Concentrations","year":2002,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Health Sciences Centre","funders":"","keywords":"Streptococcus pneumoniae; Clarithromycin; Pharmacodynamics; Microbiology; Drug resistance; Antibiotics; Antibacterial agent; Pharmacokinetics; Chemistry; Biology; Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002092573,0.000515315,0.0006540733,0.0002153893,0.0001489224,0.000690028,0.0006019555,0.001118547,0.000532985],"category_scores_gemma":[0.0007234876,0.0002721775,0.0008522454,0.0001449663,0.0001991748,0.000231035,0.0001950412,0.0003866544,0.0001695185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009994536,"about_ca_system_score_gemma":0.0008234458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01354068,"about_ca_topic_score_gemma":0.005475427,"domain_scores_codex":[0.9998405,0.00006874575,0.000008613191,0.00003094485,0.00002699079,0.00002422622],"domain_scores_gemma":[0.999582,0.0002768192,0.00006577373,0.00001005521,0.00004802563,0.00001734996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002780318,0.00007698048,0.00183093,0.00008959185,0.00005943288,0.0001318983,0.00003979263,0.9651697,0.02988681,0.000369303,0.000120412,0.001947114],"study_design_scores_gemma":[0.00002682798,0.000206209,0.001143882,0.000005807738,0.0000428229,0.00005577824,0.00002100045,0.9914431,0.006504423,0.0001356461,0.0004024667,0.00001201195],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549741,0.001094765,0.03750928,0.0003735834,0.00002768065,0.0001050074,0.001016924,0.0001519465,0.004746723],"genre_scores_gemma":[0.9948549,0.0004405945,0.003066501,0.0000413513,0.000005871841,0.00007334843,0.0002478843,0.00001469417,0.001254767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01354068,"threshold_uncertainty_score":0.02692372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114112827074738,"score_gpt":0.2826517465758686,"score_spread":0.2615106183051212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}