{"id":"W2112463583","doi":"10.1128/mcb.01653-07","title":"Functional Dissection of the NuA4 Histone Acetyltransferase Reveals Its Role as a Genetic Hub and that Eaf1 Is Essential for Complex Integrity","year":2008,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Institute of Gender and Health; National Cancer Institute; Canadian Institutes of Health Research; Government of Ontario; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Biology; Histone; Acetylation; Histone acetyltransferase; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008524052,0.0003525462,0.0001480625,0.0003648383,0.0002349086,0.0002590802,0.0003004854,0.000223122,0.001333529],"category_scores_gemma":[0.0001478344,0.0001461576,0.000221736,0.0001770616,0.0002752529,0.0002546896,0.0003821216,0.0003829012,0.0005292527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005365121,"about_ca_system_score_gemma":0.0002469412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001504519,"about_ca_topic_score_gemma":0.001652598,"domain_scores_codex":[0.99994,0.000007967697,0.000005709775,0.00001802968,0.00001553348,0.00001278864],"domain_scores_gemma":[0.999894,0.0000178535,0.00003200989,0.00001492469,0.000008645585,0.00003240149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006221898,0.00001060449,0.0007797697,0.00001829333,0.000006460734,0.00006754928,0.00001198751,0.0002460293,0.9962994,0.000321421,0.00002158877,0.002154728],"study_design_scores_gemma":[0.00001421345,0.00009762795,0.02235075,0.00001168836,0.00003193074,0.0007049089,0.00007865188,0.006455595,0.9653971,0.0005789702,0.004267509,0.00001095647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939115,0.00043211,0.004619726,0.0000618661,0.000005551814,0.000005791777,0.0002336912,0.0000647328,0.000664997],"genre_scores_gemma":[0.9939963,0.0002308086,0.003688483,0.00001824601,0.000002673721,0.000007819316,0.0005574473,0.00003115791,0.001466946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504519,"threshold_uncertainty_score":0.00446111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255335859643849,"score_gpt":0.2347711653330781,"score_spread":0.2222178067366396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}