{"id":"W2112482916","doi":"10.1124/mol.113.089649","title":"Identification of Novel Functionally Selective κ-Opioid Receptor Scaffolds","year":2013,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institute of General Medical Sciences; National Institute on Drug Abuse; Wellcome Trust","keywords":"Arrestin; Functional selectivity; Pharmacology; Dynorphin; G protein-coupled receptor; Dysphoria; Neuroscience; Opioid; Chemistry; Receptor; Medicine; Biology; Opioid peptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001817427,0.0001537998,0.0001614945,0.00007691337,0.00006076297,0.00001496441,0.0001953428,0.0001738317,0.001182897],"category_scores_gemma":[0.00002657158,0.0001602274,0.0001192897,0.0001411936,0.00006958275,0.000007810563,0.00007658522,0.00006543189,0.00006629568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002138018,"about_ca_system_score_gemma":0.00008316645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001889169,"about_ca_topic_score_gemma":8.564958e-7,"domain_scores_codex":[0.9988419,0.00007840405,0.0003310484,0.0003622732,0.0001496336,0.0002367282],"domain_scores_gemma":[0.9992185,0.00001143174,0.0001798645,0.0001753844,0.0003354759,0.00007936759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004309998,0.0001524101,0.00005306359,0.00001395478,0.0001403204,6.12445e-7,0.00003058885,0.0003689874,0.9917433,0.0002785208,0.006363858,0.0008113083],"study_design_scores_gemma":[0.00071569,0.0002184462,0.0002174879,0.000003172473,0.00003705121,0.000007578427,0.00003493727,0.0005934703,0.9930725,0.0001351604,0.004804177,0.0001603245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9320338,0.0003195433,0.06606002,0.0001690045,0.0006556857,0.0003871529,0.00001596025,0.00001592425,0.0003428715],"genre_scores_gemma":[0.9966106,0.00004817857,0.001707689,0.0005746393,0.0002013401,0.0001529822,0.0001099231,0.00002940146,0.0005652478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06457676,"threshold_uncertainty_score":0.9997302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00716458064414528,"score_gpt":0.2511987866810394,"score_spread":0.2440342060368941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}