{"id":"W2112482916","doi":"10.1124/mol.113.089649","title":"Identification of Novel Functionally Selective κ-Opioid Receptor Scaffolds","year":2013,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institute of General Medical Sciences; National Institute on Drug Abuse; Wellcome Trust","keywords":"Arrestin; Functional selectivity; Pharmacology; Dynorphin; G protein-coupled receptor; Dysphoria; Neuroscience; Opioid; Chemistry; Receptor; Medicine; Biology; Opioid peptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636671,0.0004692285,0.0003229943,0.0002265529,0.0002169166,0.0005753625,0.0005419641,0.0003091039,0.002260521],"category_scores_gemma":[0.0002579747,0.0001692804,0.000248374,0.0001538651,0.0002537141,0.0004505255,0.000416354,0.0008577867,0.0006814844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003794128,"about_ca_system_score_gemma":0.000296308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002426269,"about_ca_topic_score_gemma":0.000513657,"domain_scores_codex":[0.9998952,0.00001419548,0.000005954914,0.00002166165,0.00002090325,0.0000420891],"domain_scores_gemma":[0.999864,0.00003004323,0.00003273158,0.000018098,0.00001721937,0.00003797198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001927847,0.00004631499,0.0001276424,0.00003267847,0.000004571718,0.00008997261,0.00002229677,0.0002169611,0.9921617,0.002154486,0.0001097638,0.004840775],"study_design_scores_gemma":[0.00004808018,0.0004654544,0.00125549,0.00001042719,0.00002259977,0.0004859804,0.0000510485,0.001202894,0.9871777,0.0009263188,0.008336058,0.0000178298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646391,0.00264991,0.0248725,0.0004245935,0.00006065941,0.00007774589,0.0004821632,0.0002854652,0.006507759],"genre_scores_gemma":[0.9770104,0.002119435,0.01489327,0.000195549,0.00003532366,0.00007038027,0.0009765574,0.00004447675,0.004654634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002260521,"threshold_uncertainty_score":0.00756222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00716458064414528,"score_gpt":0.2511987866810394,"score_spread":0.2440342060368941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}