{"id":"W2112492151","doi":"10.1093/hmg/11.14.1669","title":"Nuclear genetic control of mitochondrial translation in skeletal muscle revealed in patients with mitochondrial myopathy","year":2002,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Canada; Muscular Dystrophy Association","keywords":"Biology; Mitochondrial DNA; Mitochondrial myopathy; Myogenesis; Skeletal muscle; Mitochondrion; Myocyte; Myopathy; Oxidative phosphorylation; Molecular biology; Translation (biology); Muscle tissue; Cell biology; Genetics; Gene; Biochemistry; Endocrinology; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006413232,0.0002817677,0.0003548946,0.0002028807,0.0000489995,0.00001791081,0.0002369287,0.0003187595,0.0001707665],"category_scores_gemma":[0.00004693884,0.0002954717,0.00013226,0.000219639,0.000134358,0.00000599915,0.00003718798,0.000193262,0.00001491951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000228905,"about_ca_system_score_gemma":0.00002476659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001597322,"about_ca_topic_score_gemma":0.0001410651,"domain_scores_codex":[0.9979012,0.000269937,0.0005958288,0.0005670025,0.000289194,0.0003768086],"domain_scores_gemma":[0.9990804,0.00001412818,0.0001781501,0.0005207568,0.0001079925,0.00009856553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003533729,0.0005166593,0.02227551,0.00002835274,0.00003717024,0.00003115939,0.0002663271,0.001747403,0.9719303,0.00005402873,0.0001891021,0.002570592],"study_design_scores_gemma":[0.09171209,0.01367597,0.813436,0.0002453727,0.0003598431,0.00003820661,0.0001763487,0.003501022,0.04722118,0.0004632119,0.02609674,0.003074002],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992624,0.000637895,0.005076202,0.00002819395,0.0003498344,0.0008270337,0.00002867201,0.0000113255,0.0004168364],"genre_scores_gemma":[0.9925373,0.00004773749,0.006767904,0.0001696325,0.0002255088,0.00003169964,0.0001065428,0.00006502034,0.00004864702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9247091,"threshold_uncertainty_score":0.9999498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008377769531506589,"score_gpt":0.2054296010379833,"score_spread":0.1970518315064767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}