{"id":"W2112506078","doi":"10.1016/j.mehy.2014.05.022","title":"Autologous stem cell transplant with gene therapy for Friedreich ataxia","year":2014,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Telemedicine and Advanced Technology Research Center; U.S. Department of Defense","keywords":"Frataxin; Mesenchymal stem cell; Stem cell; Biology; Ataxia; Bone marrow; Genetic enhancement; Stem-cell therapy; Transplantation; Adult stem cell; Cancer research; Cellular differentiation; Cell biology; Immunology; Medicine; Neuroscience; Gene; Genetics; Internal medicine; Iron-binding proteins","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002000904,0.0002381271,0.0002755157,0.00005178356,0.0001768282,0.00004168246,0.0005009722,0.00008871041,0.0002344451],"category_scores_gemma":[0.0002899475,0.0001567437,0.00008282004,0.000132664,0.0003166782,0.00004587102,0.00002409095,0.0001316594,0.00005290514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009913168,"about_ca_system_score_gemma":0.0001340281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005564791,"about_ca_topic_score_gemma":0.000007281496,"domain_scores_codex":[0.9977345,0.000290586,0.0002261546,0.0006094445,0.0006974897,0.0004417869],"domain_scores_gemma":[0.9978622,0.00132259,0.00007217009,0.0003654296,0.00003891897,0.000338649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009470006,0.0009258528,0.003043896,0.0001155478,0.00002229805,0.0001336195,0.0006853243,0.0001074993,0.9098603,0.001772701,0.002309125,0.08007686],"study_design_scores_gemma":[0.001224889,0.0007756141,0.001622657,0.00002060194,0.00001637453,0.00003971827,0.00001575868,0.0009149596,0.9794714,0.00026665,0.01540742,0.0002239384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979979,0.000187311,0.01736728,0.0006724003,0.0001799938,0.0005126648,0.0001046055,0.0001355157,0.0008611824],"genre_scores_gemma":[0.994362,0.0001444467,0.0005543491,0.003992804,0.0001629691,0.0001697276,0.000005168819,0.0000489329,0.0005595816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07985292,"threshold_uncertainty_score":0.6391822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03785334040970535,"score_gpt":0.2542737436872589,"score_spread":0.2164204032775535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}