{"id":"W2112506078","doi":"10.1016/j.mehy.2014.05.022","title":"Autologous stem cell transplant with gene therapy for Friedreich ataxia","year":2014,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Telemedicine and Advanced Technology Research Center; U.S. Department of Defense","keywords":"Frataxin; Mesenchymal stem cell; Stem cell; Biology; Ataxia; Bone marrow; Genetic enhancement; Stem-cell therapy; Transplantation; Adult stem cell; Cancer research; Cellular differentiation; Cell biology; Immunology; Medicine; Neuroscience; Gene; Genetics; Internal medicine; Iron-binding proteins","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002581058,0.0001474025,0.000203083,0.0002867819,0.0002247644,0.0002300943,0.0002529976,0.000530813,0.001905877],"category_scores_gemma":[0.0002405837,0.00007866328,0.0002278753,0.0002185348,0.0006229298,0.0003563247,0.0001980863,0.0003858623,0.0002290618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374342,"about_ca_system_score_gemma":0.0003002829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003222066,"about_ca_topic_score_gemma":0.0003665186,"domain_scores_codex":[0.9999532,0.000009107223,0.00000392631,0.00001046669,0.00001563828,0.000007766529],"domain_scores_gemma":[0.9999595,0.00001752693,0.000007042456,0.000007066844,0.000003415172,0.000005409715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.007432389,0.002750707,0.006733883,0.0006326812,0.0001858584,0.01051978,0.0005519835,0.01034519,0.5739812,0.06755769,0.005032477,0.3142762],"study_design_scores_gemma":[0.002962568,0.0124104,0.02224653,0.0001890158,0.0007593707,0.03404271,0.0005786097,0.02385945,0.7251273,0.1148169,0.06291642,0.00009078849],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713278,0.007614483,0.008430128,0.00126056,0.0003802604,0.00008046117,0.00009502811,0.0001035885,0.01070779],"genre_scores_gemma":[0.9918573,0.002688079,0.002838682,0.0002092719,0.0000870798,0.00002858385,0.00004555688,0.00000750185,0.002238035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001905877,"threshold_uncertainty_score":0.006375849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03785334040970535,"score_gpt":0.2542737436872589,"score_spread":0.2164204032775535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}