{"id":"W2112507995","doi":"10.1128/jvi.01086-10","title":"Early Selection in Gag by Protective HLA Alleles Contributes to Reduced HIV-1 Replication Capacity That May Be Largely Compensated for in Chronic Infection","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"Medical Research Council; Center for AIDS Research, University of Washington; Canadian Institutes of Health Research; Harvard University Center for AIDS Research; National Institutes of Health; Harvard University; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Bill and Melinda Gates Foundation; Howard Hughes Medical Institute","keywords":"Biology; Allele; Viral replication; CD8; Human leukocyte antigen; Virology; Pathogenesis; Virus; Chronic infection; Mutation; Gene; Immunology; Genetics; Immune system; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003659996,0.0001896355,0.0003130217,0.0002167293,0.0001750944,0.0005220056,0.0001186088,0.0002193822,0.001236946],"category_scores_gemma":[0.0008451391,0.0001986958,0.0001547164,0.0001416142,0.0003525784,0.0002257861,0.0002700427,0.0005124992,0.0002582387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001702952,"about_ca_system_score_gemma":0.0002558049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004516088,"about_ca_topic_score_gemma":0.0003668264,"domain_scores_codex":[0.9998187,0.00003755654,0.00001834613,0.0000399915,0.00002962648,0.00005564425],"domain_scores_gemma":[0.998906,0.0002490395,0.0003785701,0.0001730946,0.00007068659,0.0002225011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001100248,0.0001701883,0.2642892,0.00006753296,0.00003693548,0.0003892324,0.0001977618,0.0001550518,0.7237289,0.0002359556,0.00007983475,0.009549085],"study_design_scores_gemma":[0.00002297042,0.001207427,0.9615896,0.00001528588,0.00003077308,0.001786304,0.0002043769,0.0007159709,0.03376208,0.0002165318,0.0004373774,0.00001112127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994975,0.0001711301,0.0001587749,0.000008309322,0.000001321179,0.000002364119,0.00001461091,0.000004424729,0.0001415763],"genre_scores_gemma":[0.9994854,0.00009319878,0.0002011403,0.00001145973,0.000006195971,0.000003005485,0.00004184636,0.000003317236,0.0001545378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001236946,"threshold_uncertainty_score":0.004137993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0233623512502193,"score_gpt":0.29703799502224,"score_spread":0.2736756437720207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}