{"id":"W2112519486","doi":"10.1182/blood-2009-02-205153","title":"Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; McMaster University; Hamilton Health Sciences; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"EIF4E; Ribavirin; Myeloid leukemia; Cancer research; Leukemia; Medicine; Myeloid; Clinical trial; Acute leukemia; Initiation factor; Translation (biology); Biology; Oncology; Immunology; Internal medicine; Messenger RNA; Gene; Genetics; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001246212,0.0006910454,0.0009635703,0.0003158432,0.0002368081,0.0005515868,0.0005314157,0.001086737,0.002359202],"category_scores_gemma":[0.0006205944,0.0002483449,0.0005893723,0.0002125511,0.0005987002,0.0005413074,0.000303679,0.001760759,0.0003194998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000351697,"about_ca_system_score_gemma":0.0004927062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003179601,"about_ca_topic_score_gemma":0.0007228691,"domain_scores_codex":[0.9997731,0.0001232561,0.00001288507,0.00002237839,0.00002581755,0.00004251402],"domain_scores_gemma":[0.9997795,0.00006661643,0.00004976504,0.00001785408,0.00001299038,0.00007315777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4409589,0.05103676,0.002330913,0.002102781,0.0008070472,0.0004701157,0.0002960162,0.003566176,0.1039322,0.002107649,0.004463855,0.3879276],"study_design_scores_gemma":[0.4317023,0.5306457,0.006494848,0.0001481404,0.0003354206,0.0005682357,0.00007876035,0.001819022,0.01773232,0.0005969018,0.009849312,0.00002906356],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834523,0.007610002,0.00165913,0.0009921977,0.0002343227,0.002904831,0.0006907539,0.0001468392,0.002309524],"genre_scores_gemma":[0.9871795,0.005056411,0.002968791,0.000647154,0.0001753066,0.001631776,0.0006530764,0.00001657552,0.001671377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002359202,"threshold_uncertainty_score":0.00789237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867370532849957,"score_gpt":0.3086300032636587,"score_spread":0.2899562979351591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}