{"id":"W2112519486","doi":"10.1182/blood-2009-02-205153","title":"Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; McMaster University; Hamilton Health Sciences; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"EIF4E; Ribavirin; Myeloid leukemia; Cancer research; Leukemia; Medicine; Myeloid; Clinical trial; Acute leukemia; Initiation factor; Translation (biology); Biology; Oncology; Immunology; Internal medicine; Messenger RNA; Gene; Genetics; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004573514,0.0001605582,0.0004924133,0.00006996502,0.00002752031,0.000004295882,0.0001395335,0.0001000989,0.00001282481],"category_scores_gemma":[0.0001312638,0.00009609116,0.0001591786,0.0003167804,0.00007048727,0.00002957079,0.00004882726,0.0002035725,0.000003427191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005692197,"about_ca_system_score_gemma":0.0005869697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008750643,"about_ca_topic_score_gemma":0.0000102673,"domain_scores_codex":[0.9984158,0.00009798075,0.0006603044,0.0002555204,0.0003476419,0.0002228057],"domain_scores_gemma":[0.9992497,0.00005272044,0.0002242235,0.0003326873,0.00006266788,0.00007797615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06082346,0.0259939,0.7317359,0.0002941746,0.004518119,0.002614352,0.003166585,0.00018426,0.1212211,0.000987631,0.0007387442,0.04772179],"study_design_scores_gemma":[0.1521902,0.002938847,0.0459081,0.000437762,0.001124327,0.00004865158,0.00006052506,0.00005666213,0.7951244,0.0001013723,0.001764612,0.00024461],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996565,0.0002281316,0.00003484509,0.0006711077,0.00005378675,0.001028472,0.000004145172,0.00001570581,0.001398798],"genre_scores_gemma":[0.9940372,0.00002398615,0.005045888,0.00009341443,0.00006964357,0.00002761375,0.00001553426,0.00001501122,0.0006717169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6858278,"threshold_uncertainty_score":0.3918484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867370532849957,"score_gpt":0.3086300032636587,"score_spread":0.2899562979351591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}