{"id":"W2112529118","doi":"10.1093/infdis/jiu832","title":"Medroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection","year":2014,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université Laval; McMaster University Medical Centre","funders":"McMaster University","keywords":"Transcytosis; Medroxyprogesterone acetate; Endocytosis; Viral replication; Biology; Hormone; Virus; Immunology; Virology; Cell; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009754521,0.0002157535,0.0002941958,0.0002220784,0.0002003119,0.0004491054,0.0001464835,0.0002230156,0.00184925],"category_scores_gemma":[0.0001370126,0.0001374589,0.0002838501,0.0001701249,0.0002132351,0.0001637821,0.0001374203,0.0004784534,0.0005564245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003352415,"about_ca_system_score_gemma":0.0002268906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117891,"about_ca_topic_score_gemma":0.001523358,"domain_scores_codex":[0.9997975,0.00003797503,0.00001481416,0.0000266372,0.0000370153,0.00008603442],"domain_scores_gemma":[0.999909,0.00002605698,0.00001199119,0.00001173902,0.00001566702,0.00002547076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005347458,0.0000639518,0.0003347379,0.00006279296,0.000003530092,0.0001159327,0.00002594467,0.00003504166,0.9955954,0.00004103205,0.0001237161,0.003063209],"study_design_scores_gemma":[0.00004403493,0.0009241198,0.01967843,0.000009699019,0.00002163191,0.0002803349,0.0001058029,0.0003597646,0.9748526,0.00005305632,0.003663997,0.000006460643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989228,0.006558478,0.0006614497,0.0002074742,0.00010086,0.00003158673,0.0005170379,0.00008950917,0.002605523],"genre_scores_gemma":[0.9940142,0.002028719,0.0005922922,0.00007172271,0.00002618615,0.00002983137,0.0002504837,0.000009094852,0.002977599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00184925,"threshold_uncertainty_score":0.006186426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007629759400981971,"score_gpt":0.2269412866141279,"score_spread":0.2193115272131459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}