{"id":"W2112543414","doi":"10.1016/j.celrep.2015.10.008","title":"Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Michael Smith Health Research BC","keywords":"CIITA; Biology; MHC class II; Lymphoma; Major histocompatibility complex; Phenotype; Cancer research; Missense mutation; MHC class I; Genetics; Immune system; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003178472,0.0002261118,0.0004543076,0.0001451785,0.00007651889,0.0000281357,0.00003821881,0.0001327461,0.00001915866],"category_scores_gemma":[0.0001169934,0.0001735046,0.00004258436,0.0001589251,0.00003915546,0.00009682123,0.00009392558,0.00009445663,0.000003557102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008873172,"about_ca_system_score_gemma":0.0004203178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001021029,"about_ca_topic_score_gemma":0.0005218575,"domain_scores_codex":[0.9982697,0.00006679528,0.0005073631,0.0004749894,0.0003465615,0.0003346122],"domain_scores_gemma":[0.9987758,0.00007203433,0.0004318164,0.0003443262,0.00009682968,0.0002791396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001167069,0.00377489,0.9781746,0.00005469033,0.00001659566,0.01165577,0.001174607,0.00001848984,0.00274467,0.000001292034,0.002107364,0.0001603035],"study_design_scores_gemma":[0.009604466,0.0003389032,0.9773965,0.000609275,0.00007517922,0.0002643568,0.0006262198,0.00007657418,0.009929679,0.00002726351,0.0008592401,0.000192351],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924179,0.001204523,0.000003996356,0.0002748693,0.0001351945,0.000563607,0.00001633538,0.0000343162,0.005349222],"genre_scores_gemma":[0.9984568,0.00006021731,0.0001846187,0.000257344,0.00005109646,0.0001365908,0.0002589953,0.00002911824,0.0005652727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01139142,"threshold_uncertainty_score":0.7075311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678642179457296,"score_gpt":0.228801806551018,"score_spread":0.2120153847564451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}