{"id":"W2112543414","doi":"10.1016/j.celrep.2015.10.008","title":"Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Michael Smith Health Research BC","keywords":"CIITA; Biology; MHC class II; Lymphoma; Major histocompatibility complex; Phenotype; Cancer research; Missense mutation; MHC class I; Genetics; Immune system; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265334,0.0002376518,0.0001848424,0.0006564835,0.0001466712,0.0002500813,0.0001233974,0.0002157956,0.001432462],"category_scores_gemma":[0.0005000581,0.000115844,0.00009625356,0.0003150471,0.0003087776,0.0001140388,0.000177194,0.0001966846,0.0002162715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001520535,"about_ca_system_score_gemma":0.00008801214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003698644,"about_ca_topic_score_gemma":0.0005586378,"domain_scores_codex":[0.9998608,0.0000191715,0.00001157544,0.00003568797,0.0000393274,0.00003349899],"domain_scores_gemma":[0.9997088,0.0000646863,0.0001259957,0.00002738922,0.00002390373,0.00004918019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003524561,0.00003086731,0.1577401,0.00009281389,0.00004718702,0.00710154,0.0001678296,0.0001105385,0.8245048,0.0001361252,0.0001031179,0.009612718],"study_design_scores_gemma":[0.00001950027,0.0002680936,0.8166826,0.00001078841,0.00009222542,0.05964755,0.0001998184,0.0003988822,0.1204554,0.0002090316,0.002007055,0.000009098434],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980196,0.0006479216,0.0005608302,0.00001856831,0.000003077977,0.000007948815,0.00007271396,0.00002681817,0.0006426146],"genre_scores_gemma":[0.99944,0.0001360896,0.0002491422,0.000007300863,0.000004582584,0.000003215891,0.0000593981,0.000003372125,0.00009681306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432462,"threshold_uncertainty_score":0.004792035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678642179457296,"score_gpt":0.228801806551018,"score_spread":0.2120153847564451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}