{"id":"W2112582144","doi":"10.1039/c3cs35449k","title":"Progress towards the development of SH2 domain inhibitors","year":2013,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"SH2 domain; Computational biology; Signal transducing adaptor protein; Phosphotyrosine-binding domain; Proto-oncogene tyrosine-protein kinase Src; HAMP domain; Function (biology); Biology; Phosphorylation; Cell biology; Biochemistry; Chemistry; Protein domain; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006465289,0.00044133,0.002441403,0.00001877078,0.00008566512,0.00002092818,0.0003023768,0.0003434805,0.0005455604],"category_scores_gemma":[0.00009034709,0.0002137411,0.002582339,0.0003611207,0.0002844592,0.00003312921,0.0001760126,0.0006699717,0.000328579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002780241,"about_ca_system_score_gemma":0.000498205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002190927,"about_ca_topic_score_gemma":1.469811e-7,"domain_scores_codex":[0.9973183,0.00007817781,0.00163747,0.0003671787,0.0003175005,0.0002813998],"domain_scores_gemma":[0.9983819,0.00008330028,0.0007435643,0.0005271359,0.0001182431,0.0001458688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[8.669185e-7,0.00009308537,6.758428e-7,0.02622677,0.0001956101,2.859979e-7,0.0003170017,1.192523e-9,0.0003657781,0.0000111905,0.04744213,0.9253466],"study_design_scores_gemma":[0.0001093279,0.00001888613,2.841305e-7,0.03143358,0.0006495833,0.00002926025,0.00005966373,6.691101e-7,0.002006694,0.000007756354,0.9654812,0.0002030488],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003929064,0.9960232,0.0001032094,0.0001579143,0.0001688772,0.002374234,0.000007013553,0.000031916,0.001094324],"genre_scores_gemma":[0.000003178565,0.9833453,0.01453084,0.0001040905,0.0004400677,0.001013519,0.0001587471,0.00004748485,0.0003568009],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9251435,"threshold_uncertainty_score":0.8716108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1316963856223561,"score_gpt":0.3795136033462364,"score_spread":0.2478172177238802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}