{"id":"W2112583293","doi":"10.1128/jvi.00593-09","title":"Persistence of Transgene Expression Influences CD8<sup>+</sup>T-Cell Expansion and Maintenance following Immunization with Recombinant Adenovirus","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Transgene; Recombinant DNA; Persistence (discontinuity); Virology; Adenoviridae; Immunization; Molecular biology; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004339965,0.000131404,0.0002601974,0.0001098316,0.0000802335,0.000009967759,0.0002345941,0.0001418168,0.00001046502],"category_scores_gemma":[0.00003648522,0.00009612566,0.00009599231,0.0001105705,0.0001160168,0.00001834616,0.00002152262,0.0001753732,4.93463e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001326092,"about_ca_system_score_gemma":0.0001301778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004009411,"about_ca_topic_score_gemma":0.000006804053,"domain_scores_codex":[0.9988527,0.0001800873,0.0003540275,0.000184464,0.0002107388,0.0002179811],"domain_scores_gemma":[0.9992668,0.00002314888,0.0002701327,0.0002005345,0.0001606242,0.00007873768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004054764,0.0001162987,0.001589374,0.00001264786,0.00003400893,0.0000222046,0.0003226281,0.002270346,0.9876841,0.000001603244,0.00003576612,0.003856247],"study_design_scores_gemma":[0.002252498,0.01733854,0.003744722,0.0001038294,0.00003600126,0.0001420076,0.0003559818,0.0002468592,0.9752501,0.00005815886,0.0003366042,0.0001346849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945782,0.003738615,0.001242648,0.0002506306,0.00003983203,0.00009707138,0.000001532496,0.000002285545,0.00004913464],"genre_scores_gemma":[0.9962673,0.002209864,0.001231137,0.0001768258,0.00004326098,0.000001294812,0.000003731303,0.00001190857,0.0000546933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01722224,"threshold_uncertainty_score":0.3919891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273990757786582,"score_gpt":0.2610606486744176,"score_spread":0.2483207410965518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}