{"id":"W2112583293","doi":"10.1128/jvi.00593-09","title":"Persistence of Transgene Expression Influences CD8<sup>+</sup>T-Cell Expansion and Maintenance following Immunization with Recombinant Adenovirus","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Transgene; Recombinant DNA; Persistence (discontinuity); Virology; Adenoviridae; Immunization; Molecular biology; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002389009,0.0001549215,0.0001564453,0.0001202996,0.00009174606,0.0004227786,0.0001597083,0.0001687293,0.000437384],"category_scores_gemma":[0.0003520566,0.0001192235,0.0001304994,0.0000786509,0.0002246561,0.000218939,0.0001706878,0.0005268292,0.0001756012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002683521,"about_ca_system_score_gemma":0.0001752966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003210035,"about_ca_topic_score_gemma":0.0005146605,"domain_scores_codex":[0.9998139,0.00003019793,0.0000259654,0.00003298432,0.00002941519,0.00006760588],"domain_scores_gemma":[0.9997312,0.0001145453,0.00005551546,0.00003040421,0.00002816866,0.00004019124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008567721,0.00002457818,0.0004046937,0.0000117055,0.000001504504,0.00001750453,0.00002097231,0.00004393585,0.9983266,0.0000467982,0.000009074357,0.001006853],"study_design_scores_gemma":[0.00001118449,0.0004678844,0.004307055,0.00000657792,0.00001399577,0.0001043512,0.00003917379,0.0009033736,0.993363,0.0000491876,0.0007310062,0.00000320098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998454,0.0003370302,0.0008298157,0.00001616275,0.000006339163,0.00000594886,0.00003558735,0.0000157872,0.000299299],"genre_scores_gemma":[0.998396,0.0001873662,0.000713783,0.00001317266,0.000003564525,0.0000109768,0.00009725494,0.00001283213,0.0005650819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000437384,"threshold_uncertainty_score":0.001947045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273990757786582,"score_gpt":0.2610606486744176,"score_spread":0.2483207410965518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}