{"id":"W2112602352","doi":"10.1093/hmg/ddh006","title":"Reduced histone biotinylation in multiple carboxylase deficiency patients: a nuclear role for holocarboxylase synthetase","year":2003,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Biology; Biotinylation; Chromatin; Lamin; Histone; Cell nucleus; Biotin; Molecular biology; Histone H3; Pyruvate carboxylase; Nuclear lamina; Biochemistry; Cell biology; Cytoplasm; Nuclear protein; Nucleus; DNA; Enzyme; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001710482,0.0002649847,0.0002086323,0.0001111913,0.0002065761,0.00002343382,0.0001700945,0.0002948189,0.000009051339],"category_scores_gemma":[0.0002670887,0.0002772156,0.0001475873,0.0001488306,0.0001446856,0.000002876131,0.00007220622,0.0001345746,0.000008054149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004664966,"about_ca_system_score_gemma":0.00004487592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001427178,"about_ca_topic_score_gemma":0.00003529693,"domain_scores_codex":[0.9984003,0.00012007,0.0003635702,0.0005466462,0.0001586866,0.0004107101],"domain_scores_gemma":[0.9991936,0.00001256626,0.0001232175,0.0004349061,0.000134336,0.0001013787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005601477,0.0004415384,0.002562293,0.00003058511,0.00004413295,0.000006631865,0.0001713772,0.0004939315,0.9945638,0.0005732144,0.0002821677,0.0007742682],"study_design_scores_gemma":[0.006131087,0.001574626,0.01527328,0.00006040786,0.0001597398,0.00001157318,0.0004027446,0.0008464807,0.9501634,0.0006630758,0.0235261,0.001187469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927049,0.00464341,0.0004038929,0.00002639253,0.0001529302,0.0006132986,0.00003306357,0.0000219984,0.001400133],"genre_scores_gemma":[0.997282,0.0002107852,0.001970817,0.000155819,0.00003378553,0.00003823304,0.0001638348,0.00006743403,0.00007725189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04440043,"threshold_uncertainty_score":0.999968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009599460519530688,"score_gpt":0.2449081347008133,"score_spread":0.2353086741812826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}