{"id":"W2112602352","doi":"10.1093/hmg/ddh006","title":"Reduced histone biotinylation in multiple carboxylase deficiency patients: a nuclear role for holocarboxylase synthetase","year":2003,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Biology; Biotinylation; Chromatin; Lamin; Histone; Cell nucleus; Biotin; Molecular biology; Histone H3; Pyruvate carboxylase; Nuclear lamina; Biochemistry; Cell biology; Cytoplasm; Nuclear protein; Nucleus; DNA; Enzyme; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001173486,0.0007014835,0.0003466851,0.0005719016,0.0003024251,0.000335014,0.0002013335,0.0007222876,0.002602267],"category_scores_gemma":[0.0004596479,0.0002829965,0.000158068,0.0002162942,0.0004602271,0.0002466977,0.0002583552,0.0003439267,0.0003148879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392795,"about_ca_system_score_gemma":0.0001418301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008791914,"about_ca_topic_score_gemma":0.0009074438,"domain_scores_codex":[0.9998728,0.00001676945,0.00001796767,0.00005252202,0.00002536676,0.0000145218],"domain_scores_gemma":[0.999814,0.0000470668,0.00006159604,0.00001990825,0.00001781069,0.00003967703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001261902,0.00008758305,0.05174603,0.0001728616,0.00008135659,0.02889518,0.0007357242,0.0003284704,0.9023468,0.0004720286,0.0002609209,0.01361118],"study_design_scores_gemma":[0.0002244742,0.001290082,0.3589267,0.00006752066,0.0003163078,0.2682569,0.001138356,0.002324635,0.3611651,0.001534637,0.004696065,0.00005915561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985464,0.0003807307,0.0005469576,0.00006569136,0.000006978575,0.000003210385,0.00007139739,0.00002430914,0.0003543178],"genre_scores_gemma":[0.9988469,0.0001852461,0.0004832605,0.00002167274,0.000005354306,0.000002423824,0.00005406699,0.000008477777,0.0003925641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002602267,"threshold_uncertainty_score":0.008705497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009599460519530688,"score_gpt":0.2449081347008133,"score_spread":0.2353086741812826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}