{"id":"W2112602958","doi":"10.4049/jimmunol.0902738","title":"Selective Prostacyclin Receptor Agonism Augments Glucocorticoid-Induced Gene Expression in Human Bronchial Epithelial Cells","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; GlaxoSmithKline","keywords":"Glucocorticoid receptor; Agonist; Glucocorticoid; Transfection; Receptor; Reporter gene; Biology; Dexamethasone; Transrepression; Cell biology; Endocrinology; Cell culture; Transcription factor; Pharmacology; Chemistry; Internal medicine; Gene expression; Medicine; Gene; Transactivation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001865611,0.0002397637,0.0003859707,0.0002175594,0.0001071512,0.0003723279,0.0001076693,0.0001911922,0.001625147],"category_scores_gemma":[0.0001474298,0.000132138,0.0003346351,0.0001917417,0.0001460606,0.0001160356,0.0001766137,0.0005646562,0.0005871922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002290658,"about_ca_system_score_gemma":0.0001931321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007726232,"about_ca_topic_score_gemma":0.001500538,"domain_scores_codex":[0.9997088,0.00005369345,0.00002165455,0.00005313272,0.000084409,0.00007824012],"domain_scores_gemma":[0.9998842,0.00002978452,0.0000190014,0.00002483945,0.00001503464,0.00002714142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006643444,0.00002403097,0.00006996102,0.00002028698,0.000002645473,0.00002127106,0.0000150114,0.00001638945,0.9989023,0.00001773472,0.00003736678,0.0008065603],"study_design_scores_gemma":[0.00003077539,0.0007975019,0.007210934,0.000007613188,0.00002408765,0.0002164854,0.00006284026,0.0005368447,0.987075,0.00002686244,0.004005024,0.000005944965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916729,0.003084281,0.001964943,0.0002237565,0.00007110366,0.00004960177,0.0007159777,0.0001254861,0.002091981],"genre_scores_gemma":[0.9932184,0.001282178,0.001722605,0.0001098286,0.00003311774,0.00003897477,0.001055343,0.0000194627,0.002520104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625147,"threshold_uncertainty_score":0.005436659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001597980862852,"score_gpt":0.2672465359771999,"score_spread":0.2572305561685714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}