{"id":"W2112634975","doi":"10.1002/prot.20889","title":"Effect of a mutation on the structure and dynamics of an α‐helical antifreeze protein in water and ice","year":2006,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Antifreeze protein; Globular protein; Chemistry; Protein structure; Molecular dynamics; Biophysics; Helix (gastropod); Freezing point; Crystallography; Psychrophile; Protein dynamics; Biology; Biochemistry; Physics; Ecology; Computational chemistry; Thermodynamics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009627789,0.000103767,0.0001228642,0.00002459489,0.0000592709,0.00001513402,0.00004420444,0.00008584469,0.00005093553],"category_scores_gemma":[0.00002662392,0.00004671223,0.00001326468,0.0000941883,0.0002280775,0.0001234893,0.0000524664,0.0001139255,4.575635e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000127539,"about_ca_system_score_gemma":0.000001769239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000949508,"about_ca_topic_score_gemma":0.0001271046,"domain_scores_codex":[0.999418,0.00004378528,0.0002063928,0.0001021702,0.0001327038,0.00009694456],"domain_scores_gemma":[0.9997734,0.00003491626,0.00007612279,0.00007844152,0.00000802858,0.00002907649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002507648,0.00003455212,0.002661748,0.000173416,0.00000538332,3.040813e-7,0.0001754583,0.0001442052,0.95931,0.001114859,0.00000507273,0.03612423],"study_design_scores_gemma":[0.0008220676,0.001833157,0.1183892,0.00004707617,0.00002279297,0.00001277307,0.0001045132,0.06087118,0.7939736,0.02372228,0.00002540981,0.0001760112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99894,0.000005166271,0.0002532017,0.0001439873,0.000009871592,0.0005165699,0.00003731346,0.000007338299,0.00008655558],"genre_scores_gemma":[0.9985941,0.000001246336,0.001268271,0.00004257873,0.000009752029,0.000006022645,0.00006745807,0.000002579075,0.000007998231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1653365,"threshold_uncertainty_score":0.190487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003380844569904826,"score_gpt":0.1814064608454531,"score_spread":0.1780256162755482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}