{"id":"W2112698036","doi":"10.1126/scisignal.2000807","title":"Increased Abundance of Opioid Receptor Heteromers After Chronic Morphine Administration","year":2010,"lang":"en","type":"article","venue":"Science Signaling","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institutes of Health; Canadian Institutes of Health Research; Uniformed Services University of the Health Sciences; National Institute on Deafness and Other Communication Disorders; Alzheimer's Research Trust","keywords":"Homomeric; Opioid; δ-opioid receptor; Pharmacology; Receptor; Morphine; μ-opioid receptor; Chemistry; Chronic pain; G protein-coupled receptor; Neuroscience; Medicine; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104656,0.0002334259,0.0004527296,0.0003254327,0.0002320061,0.0003046426,0.0001432835,0.0002598,0.001695827],"category_scores_gemma":[0.0001399938,0.0001864982,0.0002034312,0.0001811364,0.0002838779,0.0002433966,0.0001958373,0.0009741524,0.0003346568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002053365,"about_ca_system_score_gemma":0.0001225566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004181461,"about_ca_topic_score_gemma":0.0006400732,"domain_scores_codex":[0.9997941,0.00002137655,0.00001397839,0.00004390193,0.00005537322,0.00007134581],"domain_scores_gemma":[0.999803,0.00002231381,0.0000591536,0.00002296117,0.00002030126,0.00007232942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003262477,0.00004028665,0.0003989568,0.00001489606,0.000008538951,0.00006812934,0.00002050999,0.000006929101,0.9981596,0.0000232929,0.00002305598,0.0009095658],"study_design_scores_gemma":[0.00005194478,0.00152799,0.1198959,0.00001640465,0.00006697799,0.001580941,0.0002043952,0.0006416414,0.8741979,0.0001175731,0.00168041,0.00001790151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974597,0.00101928,0.0005413165,0.00006624822,0.00002227117,0.000009975503,0.0002101629,0.00002367706,0.0006474414],"genre_scores_gemma":[0.9964343,0.0004838737,0.0006016171,0.00007849211,0.00001996121,0.00003972351,0.0003411681,0.00001719909,0.001983552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001695827,"threshold_uncertainty_score":0.00567317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526868570125353,"score_gpt":0.2651666834824185,"score_spread":0.249897997781165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}