{"id":"W2112698036","doi":"10.1126/scisignal.2000807","title":"Increased Abundance of Opioid Receptor Heteromers After Chronic Morphine Administration","year":2010,"lang":"en","type":"article","venue":"Science Signaling","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institutes of Health; Canadian Institutes of Health Research; Uniformed Services University of the Health Sciences; National Institute on Deafness and Other Communication Disorders; Alzheimer's Research Trust","keywords":"Homomeric; Opioid; δ-opioid receptor; Pharmacology; Receptor; Morphine; μ-opioid receptor; Chemistry; Chronic pain; G protein-coupled receptor; Neuroscience; Medicine; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002769922,0.0001181801,0.0001390192,0.000104682,0.0001867531,0.00006077371,0.0004760689,0.00003344678,0.0003955763],"category_scores_gemma":[0.0003431999,0.0001023189,0.00005297377,0.0005724927,0.001110965,0.0004419948,0.00008887914,0.0002159469,0.00006856651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002318086,"about_ca_system_score_gemma":0.0002722207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001883667,"about_ca_topic_score_gemma":0.000008618025,"domain_scores_codex":[0.9985479,0.00003366877,0.0002380473,0.0004971157,0.000342983,0.0003402508],"domain_scores_gemma":[0.9993296,0.00008579683,0.0001412723,0.0002577256,0.00006391758,0.0001217459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004767273,0.00003068273,0.0001890229,0.00001418894,3.863232e-7,0.00000494156,0.00004263457,0.00002688377,0.9984226,0.0005467073,0.000006596722,0.0006677036],"study_design_scores_gemma":[0.0001293306,0.0003342353,0.001881028,0.0000239053,0.000002254106,0.000009682998,0.000007958498,0.0004535443,0.9961586,0.0002953851,0.0005882246,0.0001158367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989974,0.0000114174,0.0000258839,0.00004702527,0.0004362102,0.0001189238,0.0000118663,0.00003503078,0.000316243],"genre_scores_gemma":[0.999018,0.000007163086,0.0004994128,0.0002537505,0.0001580777,0.00001037471,8.054795e-7,0.00001054743,0.00004183383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002263964,"threshold_uncertainty_score":0.4331283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526868570125353,"score_gpt":0.2651666834824185,"score_spread":0.249897997781165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}