{"id":"W2112788544","doi":"10.1186/1471-2407-8-17","title":"Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities","year":2008,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; BC Cancer Agency; University of British Columbia","funders":"Biological and Environmental Research; National Institutes of Health; National Cancer Institute; Office of Science; Michael Smith Health Research BC; U.S. Department of Energy","keywords":"Serous fluid; Loss of heterozygosity; Epigenetics; PTEN; Cancer research; Biology; DNA methylation; Germline mutation; Germline; Somatic cell; Mutation; Medicine; Pathology; Genetics; Gene; Gene expression; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003994251,0.0002708118,0.000218188,0.0008040614,0.0002407135,0.0003164363,0.0001814005,0.0002674423,0.001362135],"category_scores_gemma":[0.00144052,0.0001231948,0.0001744327,0.0003666116,0.0003887761,0.0002175807,0.0004147767,0.0001726949,0.0002820061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002173497,"about_ca_system_score_gemma":0.0002083822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005037315,"about_ca_topic_score_gemma":0.0008721511,"domain_scores_codex":[0.9997703,0.00002493571,0.00003890873,0.00004304109,0.00006022831,0.00006262777],"domain_scores_gemma":[0.9990398,0.0002631501,0.0003798994,0.00008978465,0.0001157298,0.0001114777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005433185,0.00004494089,0.9595807,0.00004622428,0.00003980301,0.002348104,0.0001504085,0.0001071005,0.02863662,0.00007326439,0.00007610535,0.008353438],"study_design_scores_gemma":[0.00002374197,0.0002035993,0.9715466,0.00001272814,0.00004068412,0.02197744,0.0002006304,0.0002001215,0.005158445,0.0001381888,0.0004932875,0.000004461516],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989975,0.0003702438,0.0001972572,0.00001087244,0.00000215224,0.0000155474,0.00005100034,0.000005407181,0.0003499985],"genre_scores_gemma":[0.9993939,0.0001365292,0.0002011559,0.0000143903,0.00000642066,0.000008445515,0.0001419694,0.000002219475,0.00009491315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362135,"threshold_uncertainty_score":0.004556835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02202225993340322,"score_gpt":0.253521751516172,"score_spread":0.2314994915827687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}