{"id":"W2112855061","doi":"10.1128/aac.48.3.930-939.2004","title":"Two Sets of Paralogous Genes Encode the Enzymes Involved in the Early Stages of Clavulanic Acid and Clavam Metabolite Biosynthesis in <i>Streptomyces clavuligerus</i>","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Streptomyces clavuligerus; Clavulanic acid; Biology; Mutant; Gene; Gene cluster; Biochemistry; Biosynthesis; Metabolite; Molecular biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004370321,0.0002577995,0.0005662423,0.0001359983,0.0000602398,0.0000346885,0.0002212947,0.0001246478,0.00001757601],"category_scores_gemma":[0.0000284354,0.0001379442,0.0001079346,0.0003452599,0.0003617565,0.00009799721,0.00004570402,0.0002074519,7.037675e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001562218,"about_ca_system_score_gemma":0.00004757654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302859,"about_ca_topic_score_gemma":0.0004306051,"domain_scores_codex":[0.9985601,0.0001145989,0.0005019127,0.0003542698,0.0001746331,0.0002945434],"domain_scores_gemma":[0.9992837,0.00008726167,0.0002099086,0.000323729,0.00005291339,0.00004245155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003946229,0.0003845942,0.1392754,0.0001824913,0.00013594,0.00001782652,0.003159254,0.000003811732,0.8450046,0.0001732928,0.0003691048,0.01089907],"study_design_scores_gemma":[0.002110406,0.0001302505,0.1959297,0.0001789578,0.00007521531,0.00002585814,0.0003751127,0.000002320335,0.799461,0.0002272104,0.001324501,0.0001595212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879019,0.003140432,0.000001508015,0.008288344,0.00004462531,0.0005319549,0.00004631272,0.00001469692,0.00003027823],"genre_scores_gemma":[0.9830194,0.01260819,0.0003754508,0.003881234,0.00006190279,0.00000228253,0.000009219471,0.00002583228,0.00001655793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0566543,"threshold_uncertainty_score":0.5625203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491549799150575,"score_gpt":0.2628527113760394,"score_spread":0.2479372133845337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}