{"id":"W2112855061","doi":"10.1128/aac.48.3.930-939.2004","title":"Two Sets of Paralogous Genes Encode the Enzymes Involved in the Early Stages of Clavulanic Acid and Clavam Metabolite Biosynthesis in <i>Streptomyces clavuligerus</i>","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Streptomyces clavuligerus; Clavulanic acid; Biology; Mutant; Gene; Gene cluster; Biochemistry; Biosynthesis; Metabolite; Molecular biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006620456,0.0006534135,0.000312151,0.0004801411,0.0001758886,0.0003691234,0.0002701519,0.0002616437,0.00123974],"category_scores_gemma":[0.0001740868,0.0001598609,0.0003754935,0.0002680084,0.0002145816,0.0001433238,0.0003940834,0.000534154,0.0008392552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004386883,"about_ca_system_score_gemma":0.0002866206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001156632,"about_ca_topic_score_gemma":0.00121705,"domain_scores_codex":[0.9998329,0.00001323566,0.00001134994,0.00005176498,0.00005658334,0.00003410699],"domain_scores_gemma":[0.9997492,0.00003693375,0.00007591783,0.00002902629,0.00002884268,0.00008003547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008385869,0.00001523953,0.0009980449,0.00002308156,0.000003671876,0.0001184507,0.000015912,0.00004903031,0.9956332,0.00006528026,0.00002204826,0.002972047],"study_design_scores_gemma":[0.00002085563,0.0002648385,0.0401938,0.000009394786,0.0000379336,0.001831852,0.0000922978,0.001021392,0.9509516,0.00009918043,0.005461553,0.0000151134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906426,0.001026821,0.005659255,0.00006228818,0.00003537594,0.00004000573,0.0009163832,0.0002092232,0.001408049],"genre_scores_gemma":[0.9778349,0.0004231001,0.006768013,0.0000484624,0.0000148163,0.00005421469,0.008517089,0.00005376222,0.006285614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123974,"threshold_uncertainty_score":0.004147351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491549799150575,"score_gpt":0.2628527113760394,"score_spread":0.2479372133845337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}