{"id":"W2112856131","doi":"","title":"A diphtheria toxin-interleukin 3 fusion protein is cytotoxic to primitive acute myeloid leukemia progenitors but spares normal progenitors.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"","keywords":"Diphtheria toxin; Myeloid leukemia; Progenitor cell; Interleukin 3; Leukemia; Biology; Molecular biology; Immunology; Nod; Bone marrow; Andrology; Stem cell; Medicine; CD8; Immune system; Toxin; Endocrinology; Interleukin 21; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003429217,0.0006055795,0.0006034174,0.0002854606,0.0004521493,0.0001149746,0.0007423924,0.0005628795,0.001787521],"category_scores_gemma":[0.0001188366,0.0005394216,0.000300873,0.0004034656,0.0001897472,0.0003241888,0.0004352669,0.000595332,0.00205851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005064739,"about_ca_system_score_gemma":0.00007765221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001326522,"about_ca_topic_score_gemma":0.00002462517,"domain_scores_codex":[0.9964653,0.0002593564,0.0006795311,0.000905279,0.0001734545,0.001517036],"domain_scores_gemma":[0.9986579,0.00004146683,0.0002599464,0.0007102242,0.0001400644,0.0001903643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004774893,0.0002745489,0.0002632835,0.00002465694,0.0004796518,0.00004337228,0.001419634,8.045041e-7,0.9239854,0.00009278926,0.004502039,0.06843629],"study_design_scores_gemma":[0.001668226,0.0004780303,0.01296191,0.00004723361,0.00008642711,0.0001552843,0.0003028381,0.00000478433,0.9362653,0.00004036118,0.04731836,0.0006711798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892277,0.0006470163,0.0001199261,0.0005721408,0.001410916,0.005833,0.0002362696,0.0003390751,0.001613923],"genre_scores_gemma":[0.9627852,0.00004820881,0.0004466774,0.0006999426,0.0002498171,0.009323577,0.00005030539,0.00009962596,0.02629666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06776511,"threshold_uncertainty_score":0.9997057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01555489115700087,"score_gpt":0.2045234614779081,"score_spread":0.1889685703209072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}