{"id":"W2112861733","doi":"10.1042/bj20020791","title":"Characterization of the human topoisomerase IIβ (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites","year":2002,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Terry Fox Foundation","keywords":"Biology; Molecular biology; Transcription factor; Promoter; Topoisomerase; Chromatin; Transcription (linguistics); Sp1 transcription factor; Gene; Transfection; DNA; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001489462,0.0002868152,0.0001880872,0.0001664598,0.00008566866,0.0002545459,0.0001397882,0.0001531427,0.0006528292],"category_scores_gemma":[0.0002319497,0.0001196684,0.0002265412,0.0001762884,0.0001453185,0.0001293499,0.0001258979,0.0004285809,0.000560045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002468134,"about_ca_system_score_gemma":0.0003444302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001260973,"about_ca_topic_score_gemma":0.0009147178,"domain_scores_codex":[0.9999164,0.00001000673,0.000005653712,0.00002155832,0.00003031819,0.00001615463],"domain_scores_gemma":[0.9998391,0.00004146405,0.00003390849,0.00001790275,0.00002771124,0.00004007046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004069191,0.00001399534,0.0002828225,0.00003045219,0.000002027369,0.00002062348,0.00001470729,0.00003722505,0.9984378,0.00002727032,0.00001218858,0.001080185],"study_design_scores_gemma":[0.00001666212,0.0001879021,0.0147709,0.00001556812,0.00001661162,0.0006063792,0.00003704075,0.001169636,0.980091,0.00006068958,0.003019675,0.000007842689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851856,0.002430747,0.00942763,0.0001277128,0.00001803393,0.00004686117,0.001990867,0.00006647103,0.0007058955],"genre_scores_gemma":[0.9768916,0.001822358,0.01209028,0.00005522084,0.00002464777,0.00005341317,0.007386083,0.00004803136,0.001628417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001260973,"threshold_uncertainty_score":0.002507329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570329353738229,"score_gpt":0.23189375544926,"score_spread":0.2161904619118777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}