{"id":"W2112861733","doi":"10.1042/bj20020791","title":"Characterization of the human topoisomerase IIβ (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites","year":2002,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Terry Fox Foundation","keywords":"Biology; Molecular biology; Transcription factor; Promoter; Topoisomerase; Chromatin; Transcription (linguistics); Sp1 transcription factor; Gene; Transfection; DNA; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006988282,0.0001125629,0.0001260995,0.0000195281,0.0001438526,0.0000332394,0.0002074065,0.0001136613,0.00007818687],"category_scores_gemma":[0.00001586238,0.00007133452,0.0001241989,0.00005944965,0.0001247852,0.000006941543,0.0001443663,0.0001630967,3.800568e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001455591,"about_ca_system_score_gemma":0.00001476131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002677143,"about_ca_topic_score_gemma":0.000002029107,"domain_scores_codex":[0.9992923,0.00005324119,0.0001918926,0.0001517767,0.0001739578,0.000136836],"domain_scores_gemma":[0.9994329,0.000002942331,0.000249235,0.0002038511,0.00006145159,0.00004963542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003175741,0.00009020999,0.0002332983,0.00001793752,0.00003799401,3.144466e-7,0.0001252156,1.09532e-7,0.9979821,0.00005811159,0.00002164115,0.001401355],"study_design_scores_gemma":[0.0003037493,0.00007958183,0.001299017,0.00004501833,0.00001991537,0.00002429049,0.00002952512,0.00001848201,0.9971561,0.00006334337,0.0008733581,0.00008757584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991316,0.0001073863,0.00006533829,0.0003616737,0.00008363259,0.0001786451,0.0000339764,0.00000247707,0.00003532563],"genre_scores_gemma":[0.9994241,0.000104505,0.00003292647,0.00005451684,0.0002531071,0.000002044054,0.000004068673,0.00001475007,0.0001099714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313779,"threshold_uncertainty_score":0.2908937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570329353738229,"score_gpt":0.23189375544926,"score_spread":0.2161904619118777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}