{"id":"W2112871554","doi":"10.1002/bit.22834","title":"A novel silicon patch‐clamp chip permits high‐fidelity recording of ion channel activity from functionally defined neurons","year":2010,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Hotchkiss Brain Institute; Institute for Biological Sciences; Institute for Microstructural Sciences","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Patch clamp; Materials science; Ion channel; Voltage clamp; Wafer; Optoelectronics; Electrophysiology; Silicon; Membrane potential; Nanotechnology; Biophysics; Chemistry; Neuroscience; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003276593,0.0004119429,0.0005603461,0.0002142748,0.0002305531,0.0006200345,0.001193171,0.0006798594,0.001303383],"category_scores_gemma":[0.0003149129,0.0003625287,0.0004371091,0.0001136936,0.0004293073,0.0006437568,0.0004719923,0.0007130492,0.0009003531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000231542,"about_ca_system_score_gemma":0.000355757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002744018,"about_ca_topic_score_gemma":0.0005687764,"domain_scores_codex":[0.9997461,0.00001706388,0.00002145453,0.0001049389,0.00008532462,0.00002510923],"domain_scores_gemma":[0.9997342,0.0001059841,0.00002889453,0.00004862715,0.0000450802,0.00003724904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001626819,0.00000830485,0.00006826945,0.0000425762,0.000005257917,0.00003383498,0.000007401986,0.00006673513,0.9964953,0.0001324528,0.00007364411,0.003049941],"study_design_scores_gemma":[0.000033701,0.00040097,0.002461493,0.00001192065,0.00005050133,0.0009504664,0.00001483308,0.003974001,0.9821801,0.0002129578,0.009683226,0.00002583304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3610376,0.003595202,0.6256073,0.0005820746,0.0003740143,0.000362725,0.001690032,0.002669245,0.004081793],"genre_scores_gemma":[0.3926348,0.002419257,0.5982127,0.0004043505,0.0001909998,0.0006421012,0.001809975,0.0001197469,0.003566129],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001303383,"threshold_uncertainty_score":0.004360199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02314775256752646,"score_gpt":0.2215774155301599,"score_spread":0.1984296629626334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}