{"id":"W2112882269","doi":"10.1016/j.chembiol.2014.11.016","title":"Antigenic Potential of a Highly Conserved Neisseria meningitidis Lipopolysaccharide Inner Core Structure Defined by Chemical Synthesis","year":2015,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"Studienstiftung des Deutschen Volkes; Max-Planck-Gesellschaft; Körber-Stiftung; Bundesministerium für Bildung und Forschung","keywords":"Neisseria meningitidis; Tetrasaccharide; Glycan; Glycoconjugate; Antigen; Lipopolysaccharide; Epitope; Microbiology; Polyclonal antibodies; Biology; Antibody; Neisseriaceae; Bacteria; Immunology; Molecular biology; Glycoprotein; Biochemistry; Antibiotics; Polysaccharide; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001663889,0.0001737789,0.00006049273,0.0001032238,0.0001414325,0.0002103932,0.000153679,0.0001289158,0.0003751238],"category_scores_gemma":[0.0001505543,0.00006177849,0.0001021185,0.00008962522,0.0002233339,0.0001321302,0.0001727975,0.0003190551,0.0001293915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002825866,"about_ca_system_score_gemma":0.0002545279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005721783,"about_ca_topic_score_gemma":0.0005642839,"domain_scores_codex":[0.9999479,0.0000122543,0.000002205059,0.000005243975,0.00001388448,0.00001866936],"domain_scores_gemma":[0.9999352,0.00001251885,0.00001387283,0.000007600066,0.00001533698,0.00001548738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001063574,0.0000237683,0.0001945972,0.00002329987,0.000002543771,0.00006498236,0.0000205113,0.0007371001,0.994814,0.001938175,0.00003623441,0.002038497],"study_design_scores_gemma":[0.00001072378,0.0003192986,0.0007072244,0.000004330499,0.000007159069,0.0001029637,0.00001918042,0.001869694,0.9945402,0.0003519923,0.002061418,0.000005972027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930753,0.0004846771,0.003671805,0.00006688257,0.00001521525,0.00001368663,0.00005413423,0.00001092244,0.002607366],"genre_scores_gemma":[0.9972836,0.00022062,0.001788441,0.00002075806,0.000004084862,0.000004915139,0.00007175296,0.000004052281,0.0006017814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005721783,"threshold_uncertainty_score":0.00205034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546202031552075,"score_gpt":0.2358477834106435,"score_spread":0.2203857630951228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}