{"id":"W2112901840","doi":"10.1200/jco.2006.09.7535","title":"Phase II Clinical Trial of Ixabepilone (BMS-247550), an Epothilone B Analog, As First-Line Therapy in Patients With Metastatic Breast Cancer Previously Treated With Anthracycline Chemotherapy","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Ixabepilone; Medicine; Anthracycline; Metastatic breast cancer; Clinical endpoint; Internal medicine; Chemotherapy; Regimen; Adverse effect; Surgery; Breast cancer; Oncology; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005718106,0.0004124623,0.003856522,0.0003739596,0.00007070278,0.000007079487,0.0002580623,0.0004455237,0.0009450078],"category_scores_gemma":[0.0003505015,0.0002413655,0.0005209834,0.0005098488,0.0007265422,0.0002369745,0.00002872533,0.001317912,0.000002885135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002666643,"about_ca_system_score_gemma":0.002064592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000380037,"about_ca_topic_score_gemma":0.001560265,"domain_scores_codex":[0.9924439,0.0007888508,0.00506198,0.0004888527,0.0006745994,0.0005417925],"domain_scores_gemma":[0.9913543,0.002305099,0.00416947,0.0003773778,0.001028105,0.000765643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4847801,0.0824802,0.2489001,0.00001855024,0.001893602,0.0005370602,0.0001591448,0.00001646374,0.00003077673,0.000002281205,0.0001855465,0.1809962],"study_design_scores_gemma":[0.3970354,0.32493,0.2745351,0.000133957,0.001037921,0.0001230734,0.00002461442,0.00002814035,0.0001169151,0.00002152721,0.001875244,0.0001380916],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915479,0.0004847257,0.00007856211,0.005308674,0.000639156,0.001729271,0.00003858708,0.00001695046,0.0001562084],"genre_scores_gemma":[0.9873452,0.00641745,0.001524684,0.002850217,0.001592141,0.00002249592,0.00004665806,0.00006055184,0.0001405625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2424497,"threshold_uncertainty_score":0.9999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1325756465646724,"score_gpt":0.5297732023901652,"score_spread":0.3971975558254929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}