{"id":"W2112901840","doi":"10.1200/jco.2006.09.7535","title":"Phase II Clinical Trial of Ixabepilone (BMS-247550), an Epothilone B Analog, As First-Line Therapy in Patients With Metastatic Breast Cancer Previously Treated With Anthracycline Chemotherapy","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Ixabepilone; Medicine; Anthracycline; Metastatic breast cancer; Clinical endpoint; Internal medicine; Chemotherapy; Regimen; Adverse effect; Surgery; Breast cancer; Oncology; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011928,0.00138272,0.001711697,0.0002855787,0.0002929382,0.0007678896,0.0007315557,0.001230838,0.003409331],"category_scores_gemma":[0.0008201923,0.000430616,0.000725884,0.0003121283,0.001032961,0.0005951923,0.0002441064,0.002671339,0.000710055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007151439,"about_ca_system_score_gemma":0.001437002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00084477,"about_ca_topic_score_gemma":0.001939752,"domain_scores_codex":[0.9997274,0.0001422922,0.00001187359,0.00003945532,0.00002380399,0.00005504363],"domain_scores_gemma":[0.9992706,0.0001189102,0.0001473407,0.0000380149,0.00003392947,0.0003911537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8079157,0.07032742,0.006528339,0.0007467307,0.0008838064,0.0003983429,0.0002454885,0.00289206,0.03596295,0.0003189787,0.004654392,0.06912576],"study_design_scores_gemma":[0.6489395,0.3359255,0.008109183,0.00003323644,0.0001953004,0.0002754075,0.00003879098,0.001524439,0.002791678,0.0001125621,0.002039824,0.00001455769],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918842,0.002588116,0.0004003473,0.0005081273,0.0001572568,0.001911197,0.0005891732,0.00009066622,0.00187078],"genre_scores_gemma":[0.9880861,0.002132222,0.001261837,0.0008902604,0.0002468668,0.002767624,0.001792008,0.00002216063,0.002800911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003409331,"threshold_uncertainty_score":0.01140535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1325756465646724,"score_gpt":0.5297732023901652,"score_spread":0.3971975558254929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}