{"id":"W2112916085","doi":"10.1210/me.2007-0080","title":"Farnesyl Pyrophosphate Is a Novel Transcriptional Activator for a Subset of Nuclear Hormone Receptors","year":2007,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute for Basic Biology; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Nursing Research","keywords":"Nuclear receptor; Biology; Receptor; Nuclear receptor coactivator 1; Farnesyl pyrophosphate; Farnesoid X receptor; Biochemistry; Orphan receptor; Estrogen-related receptor gamma; Thyroid hormone receptor; Cell biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468699,0.0002361773,0.0002691386,0.0001059579,0.00007385925,0.000007580985,0.0002414058,0.0003091787,0.00002651939],"category_scores_gemma":[0.00005817052,0.0002350724,0.0002885234,0.0001369875,0.000187956,0.000004550435,0.00006343849,0.0001622146,0.00001052071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002629132,"about_ca_system_score_gemma":0.00006336583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002160883,"about_ca_topic_score_gemma":0.000002099433,"domain_scores_codex":[0.9984303,0.00002989197,0.0003289863,0.0004481138,0.0001411183,0.0006215683],"domain_scores_gemma":[0.9992815,0.00002144037,0.0001264911,0.000327685,0.0001139714,0.0001288929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009689963,0.0001886897,0.0001387823,0.00002237214,0.0002765698,0.00001731662,0.00007213041,0.00001175356,0.99096,0.004356979,0.001308632,0.001677785],"study_design_scores_gemma":[0.002124274,0.0010066,0.0008934388,0.000006665346,0.00005636412,0.00008515514,0.00006258967,0.00002327348,0.870084,0.00009823664,0.1253262,0.0002331441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794862,0.003749544,0.0152774,0.0002952943,0.0002956635,0.0004154586,0.00006382468,0.00002661638,0.000390032],"genre_scores_gemma":[0.9951031,0.0002859091,0.003601528,0.0005291629,0.0000900686,0.00002874146,0.0001230446,0.0000625687,0.0001758806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1240176,"threshold_uncertainty_score":0.9585974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0083765319140526,"score_gpt":0.2451039899718028,"score_spread":0.2367274580577502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}