{"id":"W2112967018","doi":"10.1158/1078-0432.ccr-11-1344","title":"Skin Tumors Induced by Sorafenib; Paradoxic RAS–RAF Pathway Activation and Oncogenic Mutations of <i>HRAS</i> , <i>TP53</i> , and <i>TGFBR1</i>","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"HRAS; Sorafenib; Neuroblastoma RAS viral oncogene homolog; Cancer research; Keratinocyte; MAPK/ERK pathway; In vivo; Kinase; Malignant transformation; Medicine; Pathology; Biology; Cancer; KRAS; In vitro; Internal medicine; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362633,0.000207611,0.0002062535,0.0003007898,0.0002210074,0.0002194383,0.00009202083,0.0001548184,0.001135707],"category_scores_gemma":[0.0002333391,0.0001413733,0.0002895791,0.0001604035,0.0001613575,0.0001158645,0.0001532754,0.0002701905,0.0002296135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539916,"about_ca_system_score_gemma":0.0001116113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000208263,"about_ca_topic_score_gemma":0.0002645772,"domain_scores_codex":[0.9998529,0.00003778877,0.00001056667,0.00003067839,0.00003445704,0.00003358036],"domain_scores_gemma":[0.9997426,0.00004262277,0.0001019962,0.00002778134,0.000018423,0.0000665659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00268758,0.0002606046,0.1295263,0.0001604482,0.00007884838,0.007669427,0.000106311,0.0002180876,0.8500378,0.00007229637,0.0001214626,0.009060966],"study_design_scores_gemma":[0.0001622435,0.004696692,0.5948448,0.00001212348,0.0001370409,0.04883454,0.0002251138,0.001095287,0.3482426,0.00009299166,0.001639352,0.00001723422],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992105,0.0002308388,0.0001581515,0.000005794172,0.000002444702,0.00001015796,0.0000306181,0.00001404559,0.0003373229],"genre_scores_gemma":[0.9997229,0.00005101616,0.00009017266,0.000006663651,0.00000235342,0.000002992923,0.00004737291,0.000001292696,0.00007520791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135707,"threshold_uncertainty_score":0.003799319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1546342629104591,"score_gpt":0.4144038020313242,"score_spread":0.259769539120865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}