{"id":"W2112967018","doi":"10.1158/1078-0432.ccr-11-1344","title":"Skin Tumors Induced by Sorafenib; Paradoxic RAS–RAF Pathway Activation and Oncogenic Mutations of <i>HRAS</i> , <i>TP53</i> , and <i>TGFBR1</i>","year":2011,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"HRAS; Sorafenib; Neuroblastoma RAS viral oncogene homolog; Cancer research; Keratinocyte; MAPK/ERK pathway; In vivo; Kinase; Malignant transformation; Medicine; Pathology; Biology; Cancer; KRAS; In vitro; Internal medicine; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001325307,0.0001600551,0.0002903408,0.00006810459,0.0001397111,0.00002098402,0.0002184168,0.0002422066,0.00005030596],"category_scores_gemma":[0.0004177597,0.0001469398,0.00007628073,0.000206107,0.000495228,0.00001390341,0.0002240349,0.000394413,0.000006401178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001678624,"about_ca_system_score_gemma":0.0003607687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004469097,"about_ca_topic_score_gemma":0.000127278,"domain_scores_codex":[0.9978374,0.000401943,0.0005201531,0.0005668263,0.0002990239,0.0003746926],"domain_scores_gemma":[0.9987794,0.0002062256,0.0001498547,0.0003742089,0.0002365905,0.0002536828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004928328,0.0002493883,0.006985602,0.0000572049,0.00005250755,0.000003161191,0.000167604,3.228012e-7,0.9736841,0.0001620283,0.00304696,0.01509827],"study_design_scores_gemma":[0.001556356,0.001822512,0.0136134,0.00004898849,0.0000176013,0.000005536205,0.0001662461,0.00001101625,0.9727517,0.0006101261,0.009183065,0.0002134793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967802,0.00105102,0.0001179257,0.0001680402,0.00009809429,0.0003901645,0.00008445348,0.00001012338,0.001300018],"genre_scores_gemma":[0.9976833,0.001217,0.0001602995,0.0002279954,0.0001923743,0.0001172577,0.00007532632,0.00002888478,0.0002975392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01488479,"threshold_uncertainty_score":0.5992032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1546342629104591,"score_gpt":0.4144038020313242,"score_spread":0.259769539120865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}