{"id":"W2112974028","doi":"10.1001/archneur.61.6.849","title":"Hereditary Spastic Paraplegia","year":2004,"lang":"en","type":"letter","venue":"Archives of Neurology","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Hereditary spastic paraplegia; Genetics; Missense mutation; Locus (genetics); Haplotype; Biology; Founder effect; Mutation; Genetic heterogeneity; Genetic linkage; Phenotype; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00004824259,0.0005937956,0.0008387793,0.0004124375,0.00009609327,0.00001428478,0.001567869,0.0007481717,0.0003780336],"category_scores_gemma":[0.001242422,0.0005511149,0.0003925162,0.0002481555,0.001823698,0.00009040149,0.0004263151,0.003910488,0.0002799681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005469712,"about_ca_system_score_gemma":0.0001566402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004275841,"about_ca_topic_score_gemma":0.00000656158,"domain_scores_codex":[0.9953893,0.0009771516,0.0006702505,0.001446931,0.0004800513,0.001036284],"domain_scores_gemma":[0.9940049,0.004550726,0.0003608573,0.0009475914,0.00001246605,0.0001234724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000647305,0.0003621758,0.0002386831,0.0005196733,0.00005278843,0.04281506,0.0002113494,0.001166983,0.02549403,0.001229226,0.9246147,0.002648028],"study_design_scores_gemma":[0.001270854,0.003966388,0.003556781,0.00004429751,0.00008311473,0.001676443,0.000002041586,0.0002682443,0.002677709,0.09736047,0.8882471,0.000846563],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03861744,0.0001336283,0.0001886645,0.9373948,0.00263698,0.0006884626,0.0003074344,0.0002989871,0.01973359],"genre_scores_gemma":[0.1340857,0.0001554556,0.0001028299,0.8634443,0.001718571,0.00004113257,0.00006527836,0.0001126888,0.0002741155],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.09613124,"threshold_uncertainty_score":0.999694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03076321015054323,"score_gpt":0.2438397625001654,"score_spread":0.2130765523496222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}