{"id":"W2112985980","doi":"10.1016/s0022-2836(03)00447-9","title":"Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI","year":2003,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Cancer Institute; Fred Hutchinson Cancer Research Center","keywords":"Homing endonuclease; Isoschizomer; Endonuclease; DNA; Biology; Genetics; Restriction enzyme; Recognition sequence; Base pair; Computational biology; Homing (biology); Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004276229,0.0004172511,0.0004341284,0.0002699565,0.0001947771,0.0005504602,0.0006283892,0.0004730684,0.00103196],"category_scores_gemma":[0.0005010031,0.0003643154,0.0003478263,0.0001666711,0.0004671092,0.0002884821,0.0005702279,0.001217229,0.000551844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003286695,"about_ca_system_score_gemma":0.0001721602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002164747,"about_ca_topic_score_gemma":0.0003568357,"domain_scores_codex":[0.9996392,0.00004084614,0.00002966453,0.00008758149,0.0001087634,0.00009391295],"domain_scores_gemma":[0.9994498,0.0001117038,0.0001704778,0.0001110203,0.00004155104,0.0001153748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001185436,0.000015594,0.0001781005,0.00001060332,0.00000328425,0.00003530972,0.00001904679,0.0001502543,0.9981899,0.0003484582,0.00001502108,0.0009158619],"study_design_scores_gemma":[0.0000410872,0.0001341088,0.001635842,0.000005128858,0.00001341452,0.0002114858,0.00004736089,0.002112702,0.9949303,0.0001650934,0.0006916571,0.00001187314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908443,0.0001397236,0.007988946,0.00003283062,0.00002686573,0.00001804172,0.00004127649,0.0001070186,0.0008009738],"genre_scores_gemma":[0.9964269,0.00004953567,0.002711784,0.00002546177,0.000004684028,0.00001104552,0.0000812074,0.00003169277,0.0006578543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103196,"threshold_uncertainty_score":0.003452241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008276359288992894,"score_gpt":0.2324321369793255,"score_spread":0.2241557776903326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}