{"id":"W2112998064","doi":"10.1016/s0092-8674(00)00138-0","title":"Insights into the Molecular Basis of Leukocyte Tethering and Rolling Revealed by Structures of P- and E-Selectin Bound to SLeX and PSGL-1","year":2000,"lang":"en","type":"article","venue":"Cell","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":735,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"CYTED Ciencia y Tecnología para el Desarrollo","keywords":"Biology; Tethering; Cell biology; Selectin; E-selectin; P-selectin; Cell; Genetics; Immunology; Cell adhesion; Cell adhesion molecule; Platelet; Platelet activation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006317833,0.00022562,0.0001478709,0.0001782898,0.0003523595,0.0004312665,0.0002417379,0.0003056119,0.001287618],"category_scores_gemma":[0.0001512571,0.0001630211,0.0001327863,0.0001282428,0.0003407678,0.0004968423,0.0001709076,0.0008143422,0.0001890095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003110971,"about_ca_system_score_gemma":0.0001903705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007552663,"about_ca_topic_score_gemma":0.001051832,"domain_scores_codex":[0.9999679,0.000004892273,0.000001198624,0.000004008646,0.000009087473,0.00001289368],"domain_scores_gemma":[0.9999516,0.00001402788,0.0000141938,0.000004208439,0.000004358524,0.0000115687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002957522,0.00004640381,0.000893107,0.00004303873,0.00001550243,0.000692961,0.0001334639,0.003100575,0.9826705,0.007420762,0.0002896769,0.004398269],"study_design_scores_gemma":[0.0001970661,0.0003645783,0.0357545,0.00002879417,0.00007199404,0.001540035,0.0005534209,0.08927916,0.8506466,0.01169422,0.009810766,0.00005889357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948081,0.0005185771,0.002589033,0.0002047181,0.000008408679,0.000003534233,0.000045577,0.00002543724,0.001796603],"genre_scores_gemma":[0.9977382,0.0003430609,0.001001085,0.00004005053,0.000006589814,0.000003518773,0.00009461595,0.000004285204,0.0007685836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001287618,"threshold_uncertainty_score":0.004307508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00925487399666979,"score_gpt":0.2649181613337692,"score_spread":0.2556632873370994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}