{"id":"W2113023105","doi":"10.1093/nar/gkn152","title":"Dissection of the regulatory mechanism of a heat-shock responsive promoter in Haloarchaea: a new paradigm for general transcription factor directed archaeal gene regulation","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Biology; Haloferax volcanii; Haloarchaea; Halobacterium salinarum; Promoter; Gene; Transcription factor; General transcription factor; Transcription (linguistics); Genetics; Heat shock factor; Heat shock protein; Regulation of gene expression; Archaea; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008469257,0.0001490538,0.0002809357,0.0003400247,0.0002343887,0.00001294269,0.0002765366,0.0001939542,0.0001404413],"category_scores_gemma":[0.0002084398,0.0001129798,0.0001255955,0.000626727,0.0003689954,0.000224329,0.00006520264,0.0002570853,0.000003165501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001928132,"about_ca_system_score_gemma":0.000306023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006692127,"about_ca_topic_score_gemma":0.0003857977,"domain_scores_codex":[0.9973621,0.0005427684,0.0004610809,0.0003992471,0.0008269739,0.0004077642],"domain_scores_gemma":[0.9989251,0.000129587,0.0001021446,0.0004574633,0.0002978946,0.00008776622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001180465,0.00005160005,0.0006196497,0.00006473701,0.000009435012,0.000001562944,0.004063908,0.00008593378,0.989604,0.003479515,0.0002025214,0.0006366638],"study_design_scores_gemma":[0.0008437783,0.0004131047,0.1626781,0.00005582943,0.000006988023,0.00002511034,0.0000697248,0.002009373,0.8194807,0.01421331,0.0001069989,0.0000969701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939976,0.00007525926,0.003924444,0.0003940482,0.000335418,0.001121108,0.0000549657,0.00003896567,0.00005823133],"genre_scores_gemma":[0.9963232,0.00002185364,0.002632066,0.00001188455,0.0002065561,0.00006255294,0.00001769936,0.00002779628,0.0006963646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1701233,"threshold_uncertainty_score":0.4607183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05121392999608793,"score_gpt":0.3011868938655037,"score_spread":0.2499729638694158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}