{"id":"W2113026440","doi":"10.1158/1535-7163.mct-08-0400","title":"Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells <i>in vitro</i> via suppression of c-FLIP-s levels and activation of CD95","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Geldanamycin; MAPK/ERK pathway; Protein kinase B; Cancer research; Protein kinase A; Chemistry; p38 mitogen-activated protein kinases; Caspase 8; Kinase; Cell biology; Biology; Molecular biology; Programmed cell death; Apoptosis; Hsp90; Signal transduction; Caspase; Biochemistry; Heat shock protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001439707,0.0002663452,0.0003346597,0.000138176,0.0000730657,0.000007627264,0.0001191935,0.0001454448,0.00001831378],"category_scores_gemma":[0.00003432458,0.0002645193,0.00007427311,0.0001981616,0.0001682645,0.000009769803,0.0001035816,0.0001632074,3.06182e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002996928,"about_ca_system_score_gemma":0.00008575871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001719701,"about_ca_topic_score_gemma":0.00002453162,"domain_scores_codex":[0.9984426,0.0002059577,0.0004233378,0.0004694921,0.0001835698,0.0002750197],"domain_scores_gemma":[0.9991685,0.00002045847,0.0002246026,0.0003129999,0.0001575891,0.0001158283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008788149,0.0001084513,0.0005975266,0.00005369767,0.0000362501,0.00003082301,0.000185432,0.0001904568,0.9965869,0.000009750454,0.00008118642,0.001240724],"study_design_scores_gemma":[0.001259113,0.0006661743,0.0009583638,0.0001247034,0.00002795142,0.00004417677,0.00004128896,0.00006915438,0.9948759,0.00002555631,0.001665056,0.0002425639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905203,0.0004519374,0.008104091,0.0001064091,0.0001143248,0.0005706094,0.00007088042,0.000009899425,0.00005156851],"genre_scores_gemma":[0.9942884,0.00002825387,0.004814134,0.000440041,0.0000700554,0.00006163163,0.00004786975,0.00003930659,0.000210296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003768131,"threshold_uncertainty_score":0.9999807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153823245135176,"score_gpt":0.2646778597574336,"score_spread":0.2431396273060818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}