{"id":"W2113026440","doi":"10.1158/1535-7163.mct-08-0400","title":"Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells <i>in vitro</i> via suppression of c-FLIP-s levels and activation of CD95","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Geldanamycin; MAPK/ERK pathway; Protein kinase B; Cancer research; Protein kinase A; Chemistry; p38 mitogen-activated protein kinases; Caspase 8; Kinase; Cell biology; Biology; Molecular biology; Programmed cell death; Apoptosis; Hsp90; Signal transduction; Caspase; Biochemistry; Heat shock protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341268,0.0006551676,0.0004435574,0.0003050885,0.0001239624,0.0002251581,0.000197587,0.0002322095,0.001367169],"category_scores_gemma":[0.000108731,0.0001711417,0.0004832609,0.0001712471,0.0001798988,0.0001574023,0.0001759164,0.0005693809,0.0004090458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003248877,"about_ca_system_score_gemma":0.0003067998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005645509,"about_ca_topic_score_gemma":0.001231446,"domain_scores_codex":[0.9998419,0.00003015069,0.00001449606,0.00002088376,0.00003937897,0.00005315657],"domain_scores_gemma":[0.999912,0.00001791663,0.00002130678,0.00001346894,0.000009076512,0.00002616515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005770729,0.0001896818,0.0002373882,0.0001135917,0.0000357605,0.0001122957,0.00003217004,0.0002637195,0.9935446,0.0001283237,0.0002147129,0.004550735],"study_design_scores_gemma":[0.00009594113,0.001951953,0.002807005,0.000006180331,0.00003230652,0.0004673849,0.00002097585,0.0005329745,0.9900175,0.00004116613,0.004020728,0.000005990947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882095,0.004593959,0.001880285,0.0001692079,0.00009216624,0.0001145837,0.0004987214,0.0001929366,0.004248561],"genre_scores_gemma":[0.9902227,0.002615345,0.002910671,0.00009231085,0.00003046651,0.0001704089,0.0008493016,0.00002503106,0.003083887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001367169,"threshold_uncertainty_score":0.004573703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153823245135176,"score_gpt":0.2646778597574336,"score_spread":0.2431396273060818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}