{"id":"W2113061788","doi":"10.1093/jnci/djs221","title":"Risk of Non-Melanoma Cancers in First-Degree Relatives of CDKN2A Mutation Carriers","year":2012,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Cancer Care Ontario","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health","keywords":"CDKN2A; Proband; Cancer; Melanoma; Medicine; Relative risk; Oncology; First-degree relatives; Internal medicine; Family history; Mutation; Confidence interval; Genetics; Cancer research; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008318579,0.0003227982,0.0004312737,0.001041584,0.0003528219,0.0004338879,0.0002137671,0.0003832914,0.001120638],"category_scores_gemma":[0.00346506,0.0002068822,0.0005354984,0.0005706865,0.0001574144,0.0003080839,0.0002811881,0.0003194246,0.0001665983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194407,"about_ca_system_score_gemma":0.0001728738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00689342,"about_ca_topic_score_gemma":0.006302375,"domain_scores_codex":[0.999345,0.0002285172,0.00004651925,0.0002037138,0.0001034195,0.00007285693],"domain_scores_gemma":[0.9986437,0.0004369502,0.0005755495,0.00009691728,0.00009745354,0.0001493325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002691417,0.00001636414,0.99582,0.00001594917,0.0000860502,0.0003618022,0.00008686721,0.00006763084,0.0006110232,0.00002306873,0.00007091898,0.002571172],"study_design_scores_gemma":[0.00000873761,0.0001345402,0.9966289,0.000008790618,0.00009429981,0.002199556,0.0001353674,0.0002186967,0.0002342376,0.00005390136,0.0002765925,0.000006329797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982216,0.0009549057,0.0001769247,0.00002958816,0.000009305906,0.000004149121,0.0001848981,0.000006616621,0.0004119464],"genre_scores_gemma":[0.9994229,0.0001886009,0.0001244025,0.000009752785,0.000009001566,0.000001981505,0.00009179881,0.000001966632,0.0001495491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00689342,"threshold_uncertainty_score":0.01370662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0295351862932507,"score_gpt":0.3175434935884661,"score_spread":0.2880083072952154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}