{"id":"W2113079755","doi":"10.1136/gutjnl-2014-308553","title":"Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP","year":2015,"lang":"en","type":"article","venue":"Gut","topic":"Pancreatitis Pathology and Treatment","field":"Medicine","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"Debiopharm Group (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Medical Research Council; Cancer Research UK; Academy of Medical Sciences; China Scholarship Council; U.S. Department of Veterans Affairs; American Gastroenterological Association; National Institute for Health and Care Research; Royal College of Surgeons of England; National Institutes of Health","keywords":"Mitochondrial permeability transition pore; MPTP; Acinar cell; Pharmacology; Chemistry; Acute pancreatitis; Mitophagy; Pancreatitis; Programmed cell death; Endocrinology; Biology; Autophagy; Internal medicine; Medicine; Biochemistry; Apoptosis; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251208,0.000360147,0.0004112839,0.0002455104,0.0001813586,0.0003787493,0.0004421403,0.0004534856,0.00105686],"category_scores_gemma":[0.0001619755,0.0001264043,0.0002676662,0.0001377523,0.0004559987,0.0005017689,0.0002639941,0.0006625017,0.0002338862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003374022,"about_ca_system_score_gemma":0.0003268649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001688236,"about_ca_topic_score_gemma":0.0002226627,"domain_scores_codex":[0.9998858,0.00002016055,0.00001507679,0.00002680891,0.00002790359,0.00002430853],"domain_scores_gemma":[0.9998702,0.00001957033,0.00005451691,0.00002010939,0.00001429305,0.00002139789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003596989,0.00005953374,0.0001756292,0.0001496247,0.00001283328,0.00008538523,0.00001457046,0.00008126827,0.997075,0.0002002637,0.00003796029,0.001748266],"study_design_scores_gemma":[0.00006538996,0.0005420835,0.001965224,0.00001408106,0.0000348962,0.0004765858,0.00001761194,0.0004711259,0.9950594,0.00007202498,0.001277531,0.000004075942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820229,0.006937643,0.008935976,0.0003527497,0.00004213987,0.0000948394,0.0002554646,0.0002001228,0.00115812],"genre_scores_gemma":[0.99187,0.003004064,0.003779302,0.00004764929,0.00001315403,0.00007067864,0.0002093638,0.0000161789,0.0009895201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105686,"threshold_uncertainty_score":0.003535509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02007305447785325,"score_gpt":0.2663508261244374,"score_spread":0.2462777716465842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}