{"id":"W2113089955","doi":"10.1128/jvi.01990-07","title":"Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Biology; Complement system; iC3b; Capsid; Immune system; Adeno-associated virus; Antibody; Virology; Transgene; Innate immune system; Virus; Molecular biology; Vector (molecular biology); Immunology; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000395161,0.0006219202,0.0003041104,0.0004053367,0.0002379706,0.0004898816,0.0002369963,0.000409947,0.001567321],"category_scores_gemma":[0.0003862355,0.0001858664,0.0003076518,0.0002239056,0.0002589241,0.0002103495,0.0003326569,0.0006190251,0.0006542453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000781642,"about_ca_system_score_gemma":0.0005632087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249821,"about_ca_topic_score_gemma":0.001079411,"domain_scores_codex":[0.9994018,0.0001028698,0.0000460064,0.00009132083,0.0002671027,0.00009095716],"domain_scores_gemma":[0.9996736,0.00005197675,0.00008707607,0.00003742874,0.00009715861,0.00005272301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006743354,0.00001569283,0.0002666453,0.00009398235,0.000008705199,0.00009268761,0.00001347085,0.00004781681,0.9939475,0.000323911,0.0002197126,0.004902492],"study_design_scores_gemma":[0.00002316232,0.0004353864,0.008446544,0.00004950563,0.00002878438,0.001228299,0.00003198257,0.0009142604,0.9637081,0.0003673006,0.02474813,0.00001838992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8920892,0.03636321,0.04939887,0.000754321,0.0004957026,0.0005759186,0.001885669,0.001636839,0.01680023],"genre_scores_gemma":[0.9671234,0.00566394,0.0127443,0.0002000514,0.00006687131,0.0002373205,0.001643726,0.00008334881,0.01223716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001567321,"threshold_uncertainty_score":0.005671203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02616073386348048,"score_gpt":0.3177567598053575,"score_spread":0.291596025941877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}