{"id":"W2113089955","doi":"10.1128/jvi.01990-07","title":"Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors","year":2008,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Biology; Complement system; iC3b; Capsid; Immune system; Adeno-associated virus; Antibody; Virology; Transgene; Innate immune system; Virus; Molecular biology; Vector (molecular biology); Immunology; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009365814,0.0001244177,0.0002857003,0.0001091225,0.0001199483,0.000005209272,0.0005495379,0.0001229784,0.0001485747],"category_scores_gemma":[0.0001312933,0.00009320868,0.0001990488,0.0001350834,0.0001881364,0.000003854746,0.0001687409,0.0002113735,0.000005831005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004635602,"about_ca_system_score_gemma":0.000231068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000409541,"about_ca_topic_score_gemma":0.00009825607,"domain_scores_codex":[0.9978734,0.00084996,0.0005104189,0.0001558982,0.0003407395,0.0002695717],"domain_scores_gemma":[0.9988542,0.00003994311,0.000365976,0.0003781426,0.0002412784,0.0001204653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01668934,0.0003426656,0.001542934,0.000002035154,0.000194842,0.00001885112,0.0003321682,0.000294958,0.9791768,0.000002000793,0.001277731,0.0001257184],"study_design_scores_gemma":[0.001418886,0.009956953,0.09492298,0.000007417043,0.00002088875,0.000112966,0.00004138886,0.00002111061,0.8893961,0.00001407393,0.003999645,0.00008761653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972537,0.0005188506,0.00006923638,0.001741466,0.0002223752,0.0001474549,0.00003267533,0.000002044732,0.00001222268],"genre_scores_gemma":[0.9988391,0.0001375144,0.00007149119,0.0006984382,0.0001347016,0.000002824088,0.000006755492,0.00001835519,0.00009081013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09338005,"threshold_uncertainty_score":0.3800939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02616073386348048,"score_gpt":0.3177567598053575,"score_spread":0.291596025941877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}