{"id":"W2113114897","doi":"10.1002/anie.201203680","title":"Structure‐Based Design of a Highly Constrained Nucleic Acid Analogue: Improved Duplex Stabilization by Restricting Sugar Pucker and Torsion Angle <i>γ</i>","year":2012,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Nucleic acid; Thermostability; Duplex (building); Furanose; Dihedral angle; Torsion (gastropod); Chemistry; Oligonucleotide; Materials science; DNA; Biochemistry; Ring (chemistry); Organic chemistry; Biology; Hydrogen bond; Molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001918973,0.0003117084,0.0003050315,0.0001381712,0.000124902,0.0003829992,0.0004768228,0.0003856534,0.0009645706],"category_scores_gemma":[0.0001732165,0.0002378525,0.0002630848,0.0001257445,0.0002121603,0.0002262082,0.0002161398,0.0004370977,0.0003706776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003043457,"about_ca_system_score_gemma":0.0003399915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005203771,"about_ca_topic_score_gemma":0.0007480091,"domain_scores_codex":[0.9998977,0.00001597951,0.0000112409,0.00003169386,0.00002199993,0.00002137995],"domain_scores_gemma":[0.9998831,0.0000129647,0.00004339383,0.00001416831,0.00001477705,0.0000316659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000154867,0.00005920943,0.00006925678,0.00005042758,0.00000960065,0.00007455813,0.00002421446,0.001138595,0.995201,0.0003558373,0.0000416029,0.002820813],"study_design_scores_gemma":[0.0001122391,0.0009950825,0.000285002,0.000004426203,0.00002685597,0.0001557336,0.000009833491,0.002656471,0.9918888,0.00004928746,0.003798543,0.00001767868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839602,0.0005647411,0.01264493,0.0001005497,0.00004482381,0.0001759445,0.0002064755,0.0001195139,0.002182831],"genre_scores_gemma":[0.9780521,0.0004348554,0.01887199,0.00006375251,0.00001042362,0.0001080205,0.0002106647,0.00002640187,0.002221929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009645706,"threshold_uncertainty_score":0.003226876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009295996697808673,"score_gpt":0.2300232973993673,"score_spread":0.2207273007015586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}