{"id":"W2113114897","doi":"10.1002/anie.201203680","title":"Structure‐Based Design of a Highly Constrained Nucleic Acid Analogue: Improved Duplex Stabilization by Restricting Sugar Pucker and Torsion Angle <i>γ</i>","year":2012,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Nucleic acid; Thermostability; Duplex (building); Furanose; Dihedral angle; Torsion (gastropod); Chemistry; Oligonucleotide; Materials science; DNA; Biochemistry; Ring (chemistry); Organic chemistry; Biology; Hydrogen bond; Molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013811,0.00015927,0.0001259956,0.00004171992,0.00005767047,0.00002204907,0.0001224306,0.0001903128,0.00008825331],"category_scores_gemma":[0.0001805871,0.0001599674,0.0000499441,0.00007905253,0.0001068458,0.00003470581,0.00005346156,0.0000816338,7.824295e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004339338,"about_ca_system_score_gemma":0.0000414299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001233699,"about_ca_topic_score_gemma":0.000001519452,"domain_scores_codex":[0.9990976,0.00002506843,0.0002483995,0.0002466179,0.0001911495,0.0001911745],"domain_scores_gemma":[0.9993461,0.00002513026,0.0002018259,0.0001526345,0.000180632,0.00009372907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001105929,0.00007862406,0.001932136,0.00002662917,0.00004070552,3.663087e-7,0.00003748016,0.00001638808,0.991148,0.00001265029,0.006336355,0.0002600974],"study_design_scores_gemma":[0.0007905784,0.00009061973,0.0004148577,0.00002291233,0.0000270107,0.00000942393,0.00008137972,0.0006313539,0.995528,0.00002629118,0.002223274,0.0001543175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760513,0.0003779159,0.02219366,0.0001610516,0.0003654039,0.0001465694,0.0003560296,0.00002275708,0.0003253393],"genre_scores_gemma":[0.9942061,0.00007357731,0.001760685,0.0001661253,0.0006065313,0.00001171323,0.003100604,0.0000214408,0.00005318364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02043298,"threshold_uncertainty_score":0.652328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009295996697808673,"score_gpt":0.2300232973993673,"score_spread":0.2207273007015586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}