{"id":"W2113120539","doi":"10.1002/prot.21278","title":"Indel‐based targeting of essential proteins in human pathogens that have close host orthologue(s): Discovery of selective inhibitors for<i>Leishmania donovani</i>elongation factor‐1α","year":2007,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Indel; Biology; Leishmania; Human pathogen; Leishmania donovani; Computational biology; Pathogen; Drug discovery; Small molecule; Genetics; Biochemistry; Gene; Leishmaniasis; Visceral leishmaniasis; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006338266,0.0002999312,0.0005790898,0.0005742103,0.000197253,0.00004138361,0.00008330138,0.0002614775,0.00001125267],"category_scores_gemma":[0.0004196173,0.0002356418,0.0001382232,0.000436143,0.000249143,0.0005119719,0.00008179054,0.0004143153,2.884918e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409602,"about_ca_system_score_gemma":0.0001547099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001051308,"about_ca_topic_score_gemma":0.0006450645,"domain_scores_codex":[0.9976731,0.00005131907,0.0009882445,0.000262855,0.0006049939,0.0004194742],"domain_scores_gemma":[0.9983377,0.00009803593,0.0007198888,0.0002309148,0.0005197676,0.0000936346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002525188,0.0003138006,0.3322378,0.003799177,0.0002362626,0.000007347016,0.003944009,0.00003015476,0.647428,0.0005570373,0.0001021557,0.008819121],"study_design_scores_gemma":[0.003775985,0.00180856,0.3077262,0.0003322464,0.0000921311,0.00001103564,0.002824597,0.0009107538,0.6817444,0.000390028,0.00009869869,0.0002853522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526737,0.00009296585,0.04302644,0.00009459371,0.0001270335,0.003588895,0.0002026835,0.00003731957,0.0001563768],"genre_scores_gemma":[0.9860746,0.00001947584,0.01336269,0.00006491014,0.000128808,0.00006305752,0.0002353812,0.00002667507,0.00002443652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03431641,"threshold_uncertainty_score":0.9609195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01665352434874649,"score_gpt":0.2751802630057784,"score_spread":0.2585267386570319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}