{"id":"W2113120539","doi":"10.1002/prot.21278","title":"Indel‐based targeting of essential proteins in human pathogens that have close host orthologue(s): Discovery of selective inhibitors for<i>Leishmania donovani</i>elongation factor‐1α","year":2007,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Indel; Biology; Leishmania; Human pathogen; Leishmania donovani; Computational biology; Pathogen; Drug discovery; Small molecule; Genetics; Biochemistry; Gene; Leishmaniasis; Visceral leishmaniasis; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001834726,0.0003087402,0.000429376,0.0001613223,0.0001256591,0.0002502848,0.0002970188,0.0002656433,0.0007313734],"category_scores_gemma":[0.0001613763,0.0001569846,0.0002402502,0.00008888356,0.0002468325,0.0001730474,0.0002051256,0.0005978625,0.0003019713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001955965,"about_ca_system_score_gemma":0.0001404346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001558309,"about_ca_topic_score_gemma":0.0003622138,"domain_scores_codex":[0.999911,0.00002138325,0.000005161253,0.00001966057,0.00002603959,0.00001690403],"domain_scores_gemma":[0.9999125,0.00002229287,0.00002351377,0.000009562157,0.0000106201,0.00002153399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002053899,0.00006406252,0.0001987689,0.00006896679,0.00001248676,0.000154503,0.00001379182,0.0004268811,0.990384,0.0001484104,0.00005937689,0.008263276],"study_design_scores_gemma":[0.0001130781,0.001091457,0.0007139039,0.000004501758,0.00002872895,0.001154696,0.00001090162,0.001827602,0.9901652,0.00007947902,0.004801388,0.00000911457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686612,0.006419351,0.02219683,0.0002881322,0.00005579341,0.000131728,0.0001464765,0.0001633061,0.001937173],"genre_scores_gemma":[0.9762661,0.002995262,0.01769678,0.0002449639,0.00002109035,0.0000637224,0.0003969455,0.00003037917,0.002284733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007313734,"threshold_uncertainty_score":0.002446711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01665352434874649,"score_gpt":0.2751802630057784,"score_spread":0.2585267386570319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}