{"id":"W2113127208","doi":"10.1124/jpet.108.137497","title":"p38 Mitogen-Activated Protein Kinase-Dependent Tumor Necrosis Factor-α-Converting Enzyme Is Important for Liver Injury in Hepatotoxic Interaction between Lipopolysaccharide and Ranitidine","year":2008,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Tumor necrosis factor alpha; Liver injury; Lipopolysaccharide; Pharmacology; p38 mitogen-activated protein kinases; Protein kinase A; Endocrinology; Internal medicine; Medicine; Kinase; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003329774,0.0006427355,0.0003511787,0.0003337312,0.0003348294,0.0003376783,0.0002968634,0.0003360296,0.002744911],"category_scores_gemma":[0.0002608153,0.0003798532,0.0006319553,0.0001528055,0.0003567628,0.0005152455,0.0002403196,0.0008334586,0.000449178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003376813,"about_ca_system_score_gemma":0.0002888908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003859278,"about_ca_topic_score_gemma":0.0005174956,"domain_scores_codex":[0.9997539,0.0000556452,0.00001974261,0.00002543685,0.00005596751,0.00008925365],"domain_scores_gemma":[0.9998389,0.00001829953,0.0000486354,0.00002155862,0.00002138893,0.00005116348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00262844,0.0001900626,0.0005097943,0.000094781,0.00001632108,0.000431834,0.00003121084,0.00006287284,0.9943258,0.0003685936,0.00006203797,0.001278093],"study_design_scores_gemma":[0.00009410413,0.0006855855,0.01383408,0.00001217929,0.0000473258,0.001128601,0.0000669917,0.001393768,0.9813179,0.0001816792,0.0012299,0.000007847484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930162,0.001810009,0.003111111,0.0002232222,0.0001052374,0.00004025493,0.0001393591,0.0000692481,0.001485215],"genre_scores_gemma":[0.9946535,0.0008393745,0.001746478,0.00003665432,0.00002761955,0.00003944315,0.0002366467,0.00001093195,0.002409416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002744911,"threshold_uncertainty_score":0.009182632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1291388658542217,"score_gpt":0.4111122519771355,"score_spread":0.2819733861229138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}