{"id":"W2113187341","doi":"","title":"Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles: studies of human UDP-glucuronosyltransferases involved and substrate specificities.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Glucuronidation; Chemistry; Enzyme kinetics; Metabolite; Stereochemistry; Tertiary amine; Substrate (aquarium); Lipophilicity; UGT2B7; Enzyme; Organic chemistry; Microsome; Active site; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002300503,0.0004048435,0.0002589216,0.0001063955,0.00006851951,0.0001909562,0.0001171822,0.000210126,0.0004445969],"category_scores_gemma":[0.0002815126,0.0000944473,0.0001883927,0.0002175036,0.0001081162,0.0001577795,0.00007525215,0.0001867779,0.0002357262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873463,"about_ca_system_score_gemma":0.0001396361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009349238,"about_ca_topic_score_gemma":0.001065053,"domain_scores_codex":[0.9998719,0.00006171609,0.000007549525,0.00002362146,0.00001908915,0.00001625854],"domain_scores_gemma":[0.9998933,0.00002419301,0.00003722016,0.000007487857,0.00002154368,0.00001627387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000217437,0.00001820512,0.001125201,0.00007609231,0.00001994818,0.00005454012,0.00003261609,0.0002308774,0.9939048,0.00003173497,0.00002620057,0.00426244],"study_design_scores_gemma":[0.000005316374,0.000462265,0.005681002,0.000005243983,0.00003454753,0.0004149424,0.00001943175,0.0008156637,0.9913582,0.00001806813,0.00118034,0.000005072817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906986,0.005388117,0.002986185,0.00004421864,0.000008845313,0.00001684794,0.000178374,0.00003569376,0.0006432136],"genre_scores_gemma":[0.9920275,0.002420414,0.004001278,0.00002836833,0.000007934874,0.00001070154,0.0004919894,0.00001433727,0.0009974921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009349238,"threshold_uncertainty_score":0.002084792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2576837597796968,"score_gpt":0.4143162402860982,"score_spread":0.1566324805064014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}