{"id":"W2113192856","doi":"10.1074/jbc.m207300200","title":"Disease-causing Mutations in the Cellular Retinaldehyde Binding Protein Tighten and Abolish Ligand Interactions","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Cleveland Clinic Foundation; National Cancer Institute; National Institutes of Health; National Eye Institute; Cleveland Clinic; Foundation Fighting Blindness","keywords":"Ligand (biochemistry); Disease; Mutation; Retinaldehyde; Plasma protein binding; Chemistry; Cell biology; Genetics; Biology; Biochemistry; Receptor; Medicine; Gene; Internal medicine; Retinoic acid","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327868,0.0006751248,0.0003661238,0.0002546476,0.0001512563,0.0003073244,0.0002564899,0.000454528,0.001537199],"category_scores_gemma":[0.0002043408,0.0002025713,0.0004572933,0.0001865498,0.0003640519,0.0001493557,0.0003484841,0.0005473715,0.0009156447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003624568,"about_ca_system_score_gemma":0.0002428165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001649291,"about_ca_topic_score_gemma":0.001940563,"domain_scores_codex":[0.9998171,0.00003451632,0.00002693836,0.00003814914,0.00005763398,0.00002567341],"domain_scores_gemma":[0.999871,0.00002207395,0.00005606917,0.00001588644,0.000009666329,0.00002529092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003476661,0.00001716186,0.000340096,0.00002501607,0.00001444468,0.0003192809,0.00001291866,0.0001031872,0.9980747,0.00008749806,0.00003330504,0.0009377276],"study_design_scores_gemma":[0.00002997303,0.0002018488,0.01133956,0.00001596872,0.00005256298,0.004222026,0.00004871872,0.002179478,0.9773737,0.00008152675,0.004434856,0.00001978702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946131,0.0006818497,0.003442657,0.00009136939,0.00001480753,0.0000207711,0.0003295507,0.0002016168,0.0006042648],"genre_scores_gemma":[0.9959158,0.0002642983,0.00267286,0.00005598826,0.000004748049,0.00001502484,0.0003144566,0.00004890388,0.0007079922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001649291,"threshold_uncertainty_score":0.00514245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627535197448366,"score_gpt":0.2553294468740222,"score_spread":0.2390540948995385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}